alexa Serum Insulin and Insulin Resistance in the Off-Springs of Type 2 Diabetes Mellitus
ISSN: 2155-6156

Journal of Diabetes & Metabolism
Open Access

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Research Article

Serum Insulin and Insulin Resistance in the Off-Springs of Type 2 Diabetes Mellitus

Meraj Rahim1*, Mariam Rahim2, Masood Anwar Qureshi1, Shaheen Sharafat3, Zaman Shaikh4, Munim Abdul Rahim5 and Mubashir Zafar6

1Department of Physiology Dow University of Health Sciences, Pakistan

2Final year MBBS student, Dow Medical College, Dow University of Health Sciences, Pakistan

3Department of Microbiology, Dow University of Health Sciences, Pakistan

4Department of Medicine, Dow University of Health Sciences, Pakistan

5Institute of Isharat ul ebad of oral health sciences, Dow university of Health Sciences, Pakistan

6School of Public Health, Dow University of Health Sciences, Pakistan

*Corresponding Author:
Dr. Meraj Rahim
Assistant Professor of Physiology
Department of Physiology
Dow University of Health Sciences
Karachi, Pakistan
Tel: 92-2134014774

Received date: June 09, 2014; Accepted date: August 31, 2014; Published date: September 08, 2014

Citation: Rahim M, Rahim M, Qureshi MA, Sharafat S, Shaikh Z, et al. (2014) Serum Insulin and Insulin Resistance in the Off-Springs of Type 2 Diabetes Mellitus. J Diabetes Metab 5:425. doi: 10.4172/2155-6156.1000425

Copyright: © 2014 Rahim M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Background: Type 2 diabetes mellitus has become a universal problem. Globally 80% of lower and middle income countries are suffering from diabetes.

Aims: To determine the levels of serum insulin and to assess the insulin resistance in the offspring of diabetic parents as the predicting factors of Type 2 diabetes. Material and Methods: It is a cross-sectional study. The subjects were classified by their family history of T2DM; those with Single Diabetic Parent (SDP), Both Diabetic Parents (BDP) and No Diabetic Parents (NDP). Fasting blood sugar levels were determined by glucose oxidase and serum insulin by chemi luminescent immunometric assay. Insulin resistance was assessed by HOMA-IR index.

Results: Fasting glucose was within normal range. Mean values for fasting serum Insulin levels of three groups of subjects though fell within the normal range but the levels both in SDP and BDP were significantly higher (P 0.05) than NDP .

Conclusions: Hyperinsulinemia seems a predicting factor of T2DM in subjects who have a history of diabetes in parents.


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