alexa Serum Level and Genetic Polymorphism of Secretary Phospholipase A2-IIA in Alzheimer’s Disease | OMICS International | Abstract
ISSN: 2161-0444

Medicinal Chemistry
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Research Article

Serum Level and Genetic Polymorphism of Secretary Phospholipase A2-IIA in Alzheimer’s Disease

Hakimi S1, Marjani A2* and Khajeniazi S3

1Research Committee, Gorgan Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Golestan Province, Iran

2Metabolic Disorders Research Center, Department of Biochemistry and Biophysics, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Golestan Province, Iran

3Department of Medical Cellular and Molecular Research Center, Golestan University of Medical Sciences, Gorgan, Golestan Province, Iran

*Corresponding Author:
Abdoljalal Marjani
Metabolic Disorders Research Center
Department of Biochemistry and Biophysics
Faculty of Medicine, Golestan University of Medical Sciences
Gorgan, Golestan Province, Iran
Tel: +981714421651
E-mail: [email protected]

Received Date: October 25, 2016; Accepted Date: October 28, 2016; Published Date: October 31, 2016

Citation: Hakimi S, Marjani A, Khajeniazi S (2016) Serum Level and Genetic Polymorphism of Secretary Phospholipase A2-IIA in Alzheimer’s Disease. Med Chem (Los Angeles) 6:670-673. doi:10.4172/2161-0444.1000413

Copyright: © 2016 Hakimi S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: Alzheimer’s disease (AD) is a neurodegenerative disease and is the most common because of late life dementia. Alteration of Secretary Phospholipase A2-IIA (sPLA2-IIA) may have an important role in membrane phospholipids metabolism and the pathogenesis of AD. The aim of our study was to determine serum levels and genetic variant of sPLA2-IIA in Alzheimer’s disease and compare to controls.

Methods: This study included 40 healthy unrelated individuals and 40 patients with AD. Serum levels and the polymorphisms of sPLA2-IIA enzyme were determined.

Results: In Alzheimer patients¸ the CC genotype and C allele frequencies of enzyme were significantly lower while the CG and GG genotypes and G allele frequencies of enzyme were significantly higher than controls. The mean concentration and mean rank of enzyme for CC genotype significantly were lower while the CG and GG genotypes of enzyme were significantly higher than controls.

Conclusion: The effect of different gene polymorphisms for the incident of AD is still unclear. We determined gene polymorphisms of sPLA2-IIA which may relate to AD. It can be suggest that a single or combination of gene polymorphisms have possible effect for development of AD. Further studies are needed to research the functional roles of sPLA2-IIA in the context of AD.

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