Serum Lipid Values in Children with Beta Thalassemia Major
- *Corresponding Author:
- Vefik Arica, M.D
Medical Faculty of the Mustafa Kemal University
31100, Serinyol, Antakya, Hatay, Turkey
Tel: +90 326 2291000; +90 505 6797877
Fax: +90 326 2455654
E-mail: [email protected]
Received Date: March 12, 2012; Accepted Date: July 20, 2012; Published Date: July 23, 2012
Citation: Arica V, Arica S, Özer C, Çevik M (2012) Serum Lipid Values in Children with Beta Thalassemia Major. Pediat Therapeut 2:130. doi:10.4172/2161-0665.1000130
Copyright: © 2012 Arica V, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Objective: The purpose of the study was to examine the blood lipid profile in children with beta-Thalassemia major, and to determine the factors that affect it.
Material and Method: Files of eighty-five patients between the ages of five and fifteen with beta-Thalassemia major who were receiving regular chelation therapy followed by from paediatric policlinic of our hospital were examined retrospectively. Blood lipid profiles of fifty-five healthy children were taken for use as the control group. A total of 117 children were enrolled and examined in the study.
Findings: Hb and Hct values of the group with Beta-Thalassemia major were significantly lower than the control group (p<0.005). Ferritin values in the group with Beta-Thalassemia major were found to be significantly higher than in the control group (p<0.005). Cholesterol, HDL-cholesterol, LDL-cholesterol levels were found to be significantly lower in patients with Beta-Thalassemia major than in the control group (p<0.001), while the triglyceride level was found to be higher (p<0.001).
Result: We determined a positive correlation between triglyceride and serum ferritin levels. It may indicate excessive iron loading, and changes in blood lipid values in patients with Beta-Thalassemia major.