alexa Serum Melatonin Level Disturbance is Related to Metabolic Syndrome and Subclinical Arterial Dysfunction in Shift Working Healthy Men
ISSN: 2167-0943

Journal of Metabolic Syndrome
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Research Article

Serum Melatonin Level Disturbance is Related to Metabolic Syndrome and Subclinical Arterial Dysfunction in Shift Working Healthy Men

Radina Eshtiaghi1* and Ali Reza Khoshdel2,3
1Department of Internal Medicine, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran
2Department of Epidemiology, Faculty of Medicine, AJA University of Medical Sciences, Tehran, Iran
3Department of Nephrology, John Hunter Hospital, The University of Newcastle, NSW, Australia
Corresponding Author : Ali Reza Khoshdel
Department of Epidemiology
Faculty of Medicine
AJA University of Medical Sciences
Etemadzadeh Avenue, Fatemi Street
Tehran, Iran, PO Box: 16315-781
Tel: +982126317336
Fax: +982188337909
E-mail: [email protected]
Received August 31, 2013; Accepted September 24, 2013; Published September 26, 2013
Citation: Eshtiaghi R, Khoshdel AR (2013) Serum Melatonin Level Disturbance is Related to Metabolic Syndrome and Subclinical Arterial Dysfunction in Shift Working Healthy Men. J Metabolic Synd 2:128. doi:10.4172/2167-0943.1000128
Copyright: © 2013 Eshtiaghi R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: NW (night work) and SW (shift work) are associated with increased risk for metabolic conditions and cardiovascular disease. This study was planned to evaluate serum melatonin level related to metabolic syndrome and subclinical vascular consequences in shift working men.

Methods: Eighty-six shift working healthy men between 30-55 years old were studied. Anthropometric parameters and fasting blood glucose, lipids, Ox-LDL, Insulin and morning melatonin were measured. Pulse wave analysis was performed via SphygmoCor® to obtain surrogate markers for arterial stiffness.

Results: Of the 86 subjects, 19 (21.1%) had metabolic syndrome . Serum melatonin level was significantly lower in subjects with metabolic syndrome compared with normal group (p = 0.014). Insulin resistance was present in 27(30.7%) of cases .In addition, Serum melatonin was higher in group with Framingham’s risk score ≤ 5% versus group with scores ≥5% (p=0.02). Melatonin had inverse correlation with radial and aortic systolic pressures P= 0.005, p=0.02, radial and aortic pulse pressures (P < 0.001, p=0.0001) and cardiac end systolic pressure,( p=0.03), respectively. Odds ratio of low melatonin level (<50%) for Pulse pressure amplification ≤ 75% quartile was 3.25, P=0.02.

Conclusions: Taken together, the inverse relationship of melatonin level and metabolic syndrome and Framingham risk score as well as peripheral and central blood pressure, cardiac end systolic pressure, and its direct relation to pulse pressure amplification highlighted its potential impact on pathogenesis of metabolic syndrome and arterial stiffness.

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