alexa Serum Prolactin and ImmunoglobulinE Levels in Psoriasis Vulgaris before and after NB-UVB Therapy
ISSN: 2161-0444

Medicinal Chemistry
Open Access

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Research Article

Serum Prolactin and ImmunoglobulinE Levels in Psoriasis Vulgaris before and after NB-UVB Therapy

Mamoun Elsayed Shalaby1, Hassan M Hassan1, Mohammed I Aref2* and Asmaa D Ebeid1

1Department of Dermatology and Venereology, Faculty of Medicine, Al Azhar University, Egypt

2Department of Clinical Pathology, Faculty of Medicine, Al Azhar University, Egypt

*Corresponding Author:
Mohammed I. Aref
Department of Clinical Pathology
Faculty of Medicine
Al Azhar Universty Cairo, Egypt
Tel: 02-1154000554
E-mail:
[email protected]

Received date: July 23, 2015; Accepted date: September 11, 2015; Published date: September 17, 2015

Citation: Shalaby ME, Hassan HM, Aref MI, Ebeid AD (2015) Serum Prolactin and ImmunoglobulinE Levels in Psoriasis Vulgaris before and after NB-UVB Therapy. Med chem 5:432-436. doi: 10.4172/2161-0444.1000296

Copyright: © 2015 Shalaby ME, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Babkground: Psoriasisis a chronic, inflammatory, T-cell mediated autoimmune disease. Many data demonstrating a significantly increased serum levels of both prolactin and IgE in patients with psoriasis vulgaris and reporting an association between their level and psoriasis severity. Existence of prolactin receptors on epidermal keratinocytes provides more support for the hypothesis that prolactin might have a role in the etiogenesis of psoriasis. Objectives of the study: It was aimed to estimate serum prolactin and immunoglobulin E levels in psoriasis vulgaris before and after NB-UVB therapy. Patients and methods: Fifty patients were submitted in this study. Severity of psoriasis was calculated using PASI score. Results: The results showed the following; a statistically significant difference between patients before and after NB-UVB therapy regarding PASI score (P=0.001), a statistically insignificant difference between patients before and after NB-UVB therapy regarding prolactin level (P=0.06), a statistically significant difference between patients before and after NB-UVB therapy regarding IgE level (P=0.0003), a statistically insignificant correlation between PASI score and prolactin level before NB-UVB therapy (P=0.506), a statistically insignificant correlation between PASI score and prolactin level after NB-UVB therapy (P=0.793), a statistically insignificant correlation between PASI score and IgE level before NB-UVB therapy (P=0.074), and a statistically significant correlation between PASI score and IgE level after NB-UVB therapy (P=0.01). Conclusion: The present study concluded that serum prolactin level is elevated in psoriasis vulgaris but there is no correlation of its level with psoriasis severity. Also, serum IgE level is elevated in psoriasis vulgaris and there is a significant correlation between its levels with psoriasis severity

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