Serum Prolactin Level and Diabetic Retinopathy in Type 2 Diabetes Prolactin and Diabetic RetinopathyBonakdaran Shokoofeh1, Shoeibi Nasser2, Mojtaba Abrishami2 and Rokni Haleh1*
- *Corresponding Author:
- Rokni Haleh
Endocrine Research Center
Mashad University of Medical Sciences, Iran
E-mail: [email protected]
Received date: October 16, 2011; Accepted date: Feberuary 15, 2012; Published date: Feberuary 20, 2012
Citation: Shokoofeh B, Nasser S, Abrishami M, Haleh R (2012) Serum Prolactin Level and Diabetic Retinopathy in Type 2 Diabetes. J Diabetes Metab 3:173. doi:10.4172/2155-6156.1000173
Copyright: © 2012 Shokoofeh B, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Retinopathy is a common complication of type 2 diabetes. Several factors including hyperglycemia and hypertension play important roles in retinopathy progression. However, the actual mechanistic pathways are not yet discovered. Prolactin via its antiangiogenic characteristics may exert protective effects on retina. We performed a case- control study in order to investigate the potential role of 23KD prolactin in retinopathy.
A total of 212 type 2 diabetics were recruited in this study. According to retinopathy they were divided into two groups. Group one (70 patients) suffered diabetic retinopathy and group two (142 patients) did not have retinopathy. There were significant differences in diabetes duration and hyperglycemia and systolic hypertension between two groups (p<0.05). However we did not find any significant difference in prolactin level between two groups (p>0.05). Serum 23 KD prolactin does not seem to have protective role in diabetes retinopathy.