alexa Serum Soluble CD30 Levels to Detect Activation and Aggression Status of Adult T-Cell Leukemia/Lymphoma Cells | OMICS International | Abstract
ISSN: 2329-8790

Journal of Hematology & Thromboembolic Diseases
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Short Communication

Serum Soluble CD30 Levels to Detect Activation and Aggression Status of Adult T-Cell Leukemia/Lymphoma Cells

Shigeki Takemoto1,2,*, Ratiorn Pornkuna2,3 and Chie Nishioka4
1Clinical Laboratory, National Hospital Organization Kumamoto Medical Center, Kumamoto, Japan
2Department of International Cooperation, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
3Nursing Department, Khon Kaen Regional Hospital, Khon Kaen, Thailand
4Department of Hematology and Respiratory Medicine, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan
Corresponding Author : Dr. Shigeki Takemoto
M.D., Ph.D., Chief of Clinical laboratory
National Hospital Organization Kumamoto Medical Center, 1-5 Ninomaru
Kumamoto 860-0008, Japan
Tel: +81-(0)96-353-6501
Fax: +81-(0)96-325-2519
E-mail: [email protected]
Received February 14, 2015; Accepted April 23, 2015; Published April 30, 2015
Citation: Takemoto S, Pornkuna R, Nishioka C (2015) Serum Soluble CD30 Levels to Detect Activation and Aggression Status of Adult T-Cell Leukemia/Lymphoma Cells. J Hematol Thrombo Dis 3:205. doi: 10.4172/2329-8790.1000205
Copyright: © 2015 Takemoto S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
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Abstract

Adult T-cell leukemia/lymphoma (ATL) is one of aggressive mature T-cell malignancies. CD30 is a cell membrane protein expressed on activated T-cell. While a limited number of ATL cells show the CD30 expression, high levels of soluble CD30 (sCD30) are detected in serum of ATL patients. It is known that a disintegrin and metalloproteinase (ADAM)10 and ADAM17 are ubiquitously expressed in peripheral leukocytes including T cells. They are sheddases of CD30 and IL-6 receptor (IL-6R) from cell surface as well as cleaving enzymes of E-cadherin and extracellular matrix. High levels of sIL-6R/IL-6 complex induce CRP production in the liver of ATL patients. Therefore the elevation of sCD30 and CRP levels indirectly indicated the activation status of ATL cells and the risk of invasion and tissue injury of important organs such as lung via metalloproteinases activation on ATL cells in vivo. Activated ATL cells may play a role for clinical aggression in ATL.

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