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ISSN: 2155-6156

Journal of Diabetes & Metabolism
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Research Article

Serum Uric Acid and Homocysteine as Predictors of Pre-eclampsia

Sangeeta N1, Shaini L1, Gomi Basar1*, Soni Devi1, Vanlal Chhuangi1, Kanak Kanti Mandal1, Radhe Natung2, Ajit Kumar Y3, Singh WG1 and Amuba Singh M1

1Department of Biochemistry, RIMS, India

2Maulana Azad Medical College, New Delhi, India

3Department of Obstetrics and Gynaecology, RIMS, India

*Corresponding Author:
Gomi Basar, PGT
Department of Biochemistry
Regional Institute of Medical Sciences
Imphal, Manipur, India-795004
Tel: +91 9436042415/+91 9774024415
Fax: 0385-2414625
E-mail: [email protected]

Received date: March 27, 2013; Accepted date: April 23, 2013; Published date: April 28, 2013

Citation: Sangeeta N, Shaini L, Basar G, Soni Devi, Chhuangi V, et al. (2013) Serum Uric Acid and Homocysteine as Predictors of Pre-eclampsia. J Diabetes Metab 4:259. doi:10.4172/2155-6156.1000259

Copyright: © 2013 Sangeeta N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Abstract

Objective: To estimate the serum homocysteine and uric acid levels in normal and pre-eclamptic patients and to find out any correlation between these parameters and pre-eclampsia

Study design and setting: Cross-sectional study; Dept. of Biochemistry in collaboration with Department of Obstetrics and Gynaecology, Regional Institute of Medical Sciences (RIMS); Imphal (Manipur), India.

Methods: Data collected from 50 pre-eclamptic pregnant women and 25 normotensive pregnant women admitted in Antenatal ward, Department of Obstetrics and Gynaecology, RIMS Hospital. The blood samples were collected from these patients and analyzed for serum homocysteine and uric acid level.

Results: The serum homocysteine and uric acid levels were found to be significantly higher in preeclamptic cases than in normal controls. Mean ± SD of uric acid and homocysteine levels were 8.82 ± 1.68 mg% and 10.32 ± 2.52 μmol/l respectively in the cases compared to 4.06 ± 0.96 mg% and 3.55 ± 1.25 μmol/l in the controls. A positive correlation was found between the serum uric acid level, homocysteine and blood pressure. Thus the study showed a strong association between increased uric acid, blood pressure and homocysteine levels.

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