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Journal of Clinical & Experimental Cardiology
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Research Article

Serum Uric Acid As An Independent Predictor of Cardiovascular Event In Patients With Acute ST Elevation Myocardial Infarction

Surya Dharma1*, Bambang Budi Siswanto1, Sunarya Soerianata1, Alexander J Wardeh2 and Jan Wouter Jukema3
1Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia
2Department of Cardiology, M.C Haaglanden, The Hague, The Netherlands
3Professor of Cardiology, Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
Corresponding Author : Surya Dharma
Department of Cardiology and Vascular Medicine
Faculty of Medicine, University of Indonesia
National Cardiovascular Center Harapan Kita
Jl S Parman Kav 87, Slipi, Jakarta Barat 11420
Jakarta, Indonesia
Tel: +628121083601
Fax: +62 21 5684220
Email: [email protected]
Received March 09, 2012; Accepted March 23, 2012; Published March 25, 2012
Citation: Dharma S, Siswanto BB, Soerianata S, Wardeh AJ, Jukema JW (2012) Serum Uric Acid As An Independent Predictor of Cardiovascular Event In Patients With Acute ST Elevation Myocardial Infarction. J Clinic Experiment Cardiol S5:005. doi:Serum Uric Acid As An Independent
Copyright: © 2012 Dharma S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Background: There is uncertainty whether uric acid level could be used as a prognostic marker in acute ST elevation myocardial infarction (STEMI) patients. Furthermore, there is a need to find a simple, less expensive but accurate marker that could be use in rural areas where fibrinolytic treatment is the first choice of acute reperfusion therapy. We studied the association of uric acid levels on cardiovascular event in patients with STEMI receiving fibrinolytic treatment.
Methods: Seventy-five patients with acute STEMI, eligible for fibrinolytic therapy, were enrolled in this cohort study. Over a night of fasting period, uric acid level was measured. One month clinical follow up was done. Reinfarction, heart failure, urgent revascularization, recurrent angina and death were defined as end point of the study.
Results: In STEMI patients with lowest uric acid levels (<4.8 mg/dl) compared with highest uric acid levels (>7.3 mg/dl), the cardiovascular event rate increased from 8% to 20%. From multivariate Cox regression analysis showed that elevated levels of uric acid (>7.3 mg/dl) demonstrated an independent, significant positive relation to cardiovascular events [Hazard Ratio 3.10 (95% Confidence Interval 1.16 to 8.29), p <0.024].
Conclusion: Serum uric acid is an independent predictor of cardiovascular event in patients with post fibrinolytic treatment in acute STEMI.

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