Severe Course of Juvenile GraveÃ¢ÂÂs Disease accompanied by Myasthenia GravisJustyna Kubiszewska and Anna Kostera-Pruszczyk*
Department of Neurology, Medical University of Warsaw, Poland
- Corresponding Author:
- Anna Kostera-Pruszczyk
Department of Neurology, Banacha 1a
02-097 Warsaw, Poland
Fax: +48 22 5991857
E-mail: [email protected]
Received date: October 22, 2014; Accepted date: December 15, 2014; Published date: December 20, 2014
Citation: Kubiszewska J, Kostera-Pruszczyk A (2014) Severe Course of Juvenile Grave’s Disease accompanied by Myasthenia Gravis . J Neurol Neurophysiol 5:259. doi:10.4172/2155-9562.1000259
Copyright: © 2014 Kubiszewska J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Grave’s disease is the most common cause of hyperthyroidism in children. Symptoms of hyperthyroidism associated with Grave’s disease include goiter, tachycardia, tremor or diplopia caused by exophthalmos. Marked fatigue and weight loss may be observed due to hypermetabolic state. Myasthenia Gravis is far less frequent, with juvenile onset in fewer than 10% of the patients. Ocular symptoms: ptosis or diplopia, and weakness and fatigability of limb and bulbar muscles are hallmarks of myasthenia. In some of the patients Grave’s disease and myasthenia may mimic each other though coincidence of both diseases can be also observed. We report the case of a girl with abrupt onset of hyperthyroidism with severe dysphagia and weight loss. Family history positive for Grave’s disease and laboratory results confirming hyperthyroidism delayed diagnosis and treatment of her severe myasthenia.