alexa Short-Term Exposure to Haze Air Pollution Induces Acute Airway Inflammation and Lung Function Reduction in Healthy Adult Subjects | OMICS International| Abstract
ISSN: 2161-0525

Journal of Environmental & Analytical Toxicology
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  • Research Article   
  • J Environ Anal Toxicol 2018, Vol 8(2): 555
  • DOI: 10.4172/2161-0525.1000555

Short-Term Exposure to Haze Air Pollution Induces Acute Airway Inflammation and Lung Function Reduction in Healthy Adult Subjects

Haibin Li1,2, Yanqin Liu3, Sanqiao Yao1,2, Yuefei Jin4, Yixin Luo1,2, Wenyang Li1,2, Chengyu Song1,2, Chonglun Liu1,2, Ziye Wang1,2 and Weidong Wu1,2*
1Department of Occupational and Environmental Health, , PR China
2Henan International Collaborative Laboratory for Health Effects and Intervention of Air Pollution, School of Public Health, , PR China
3School of Foreign Languages, Xinxiang Medical University, Xinxiang, Henan Province 453003, PR China
4Department of Epidemiology, College of Public Health, Zhengzhou University, Henan Province 450001, PR China
*Corresponding Author : Weidong Wu PhD, School of Public Health, Xinxiang Medical University, 601 Jinsui Street, Xinxiang, Henan Province 453003, PR China, Tel: 863733831051, Email: [email protected]

Received Date: Jan 10, 2018 / Accepted Date: Feb 20, 2018 / Published Date: Feb 25, 2018


Haze air pollution with high levels of PM has frequently took place in many areas of China in the past few years. However, the health effect of shirt-term exposure to haze air pollution has not been thoroughly characterized. This study aimed to determine the acute effect of haze exposure on respiratory system of healthy adult subjects, specifically on airways and lung function. Thirty healthy adult subjects were recruited and airway inflammation and lung function alterations examined under control and haze air pollution (157.33 μg/m for mean concentration of PM ) conditions, respectively. Airway inflammation was assessed by sputum induction while lung function was measured using spirometry. It was shown that 24-h exposure to haze air pollution could increase the levels of inflammatory mediators including interleukin-6 (IL-6), IL-8, and tumor necrotic factor-α (TNF-α), as well as the percentages of eosinophils, neutrophils, and lymphocytes in the sputum (<0.05). In contrast, the proportion of macrophages in the sputum from haze-exposed subjects decreased significantly (<0.05). In addition, short-term exposure to haze could decrease forced vital capacity (FVC), forced expiratory volume in the first second (FEV ), vital capacity (VC), and maximum voluntary ventilation (MVV), but not FEV1/FVC. In summary, short-term exposure of healthy adult subjects to haze air pollution induces airway inflammation and lung function impairment.

Keywords: Haze; Airway inflammation; Lung function; Sputum induction

Citation: Li H, Liu Y, Yao S, Jin Y, Luo Y, et al. (2018) Short-Term Exposure to Haze Air Pollution Induces Acute Airway Inflammation and Lung Function Reduction in Healthy Adult Subjects. J Environ Anal Toxicol 8: 555. Doi: 10.4172/2161-0525.1000555

Copyright: © 2018 Li H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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