alexa Short-Term Memory Impairment Sparing the Central Executive in Relapsing- Remitting Multiple Sclerosis? | OMICS International | Abstract
ISSN: 2155-9562

Journal of Neurology & Neurophysiology
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Research Article

Short-Term Memory Impairment Sparing the Central Executive in Relapsing- Remitting Multiple Sclerosis?

Ehrlé Nathalie1-3*, Omigie Diana2-4, Saenz Amaya1,2, Debouverie Marc5, Rumbach Lucien6, Chaunu Marie-Pierre1 and Bakchine Serge1-3

1Service de Neurologie, CHU de Reims, France

2Equipe de Neuropsychologie et Cognition auditive, Laboratoire de Neurosciences Fonctionnelles et Pathologies EA 4559, Université de Lille-Nord de France, France

3Centre mémoire de recherche et de ressources (CMRR) de Champagne-Ardenne, France

4Hôpital de la Pitié-Salpêtrière, Paris, France

5Service de Neurologie and Faculté de Médecine, CHU de Nancy, France

6Service de Neurologie and Faculté de Médecine, CHU de Besançon, France

Corresponding Author:
Nathalie Ehrle
Service de Neurologie, CHU de Reims 45
rue Cognacq Jay, 51092 Reims Cedex, France
Tel: 33326783964/3089
Fax: 33326832668
E-mail: [email protected]

Received date: February 24, 2014; Accepted date: March 22, 2014; Published date: March 28, 2014

Citation: Nathalie E, Diana O, Amaya S, Marc D, Lucien R, et al. (2014) Short-Term Memory Impairment Sparing the Central Executive in Relapsing-Remitting Multiple Sclerosis?. J Neurol Neurophysiol 5:202. doi:10.4172/2155-9562.1000202

Copyright: © 2014 Ehrle N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Objective: It is widely accepted that working memory (WM) impairment has a high incidence in multiple sclerosis
(MS). However, this WM impairment has rarely been analyzed with reference to a cognitive model. The aim of the
study was to determine whether dysfunction in MS is due to WM or short-term memory deficits.
Methods: We assessed the components of Baddeley's WM cognitive model, which include the phonological loop,
visual sketch and central executive. Seventeen conditions implicating short term memory and executive functions
(flexibility, inhibition, manipulation) were carried out by128MS patients diagnosed with RRMS, and 30 age matched
healthy controls. Also assessed were three tasks of motor speed namely the Overt articulation rate, Digit-symbol
copy test and Digit-symbol coding test.
Results: In all but three conditions, the MS group scored significantly below the control group (Mann-Whitney
tests), suggesting a short-term memory deficit in MS. However, when performances in the central executive
conditions were expressed proportionally to a baseline, the patient group behaved in a similar way to the control
group. Finally, no relationship could be shown between the impairment in WM tasks and the motor speed tasks.
Conclusions: Our results suggest an impairment of short-term memory in MS patients but with a relative
preservation of WM. Critically, this conclusion is not in agreement with the widespread notion of WM deficit in MS


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