Side-by-Side Epigenetics and Genetics Share Importance in Cancer DevelopmentAna Paula de Souza-Pardo*
Department of Morphology, School of Dentistry of Piracicaba, University of Campinas, Brazil
- *Corresponding Author:
- Souza-Pardo APD
Department of Morphology
School of Dentistry of Piracicaba
University of Campinas Limeira Avenue, 901
13414-018 Piracicaba-SP Brazil
E-mail: [email protected]
Received October 09, 2014; Accepted October 14, 2014; Published October 16, 2014
Citation: Souza-Pardo APD (2015) Side-by-Side Epigenetics and Genetics Share Importance in Cancer Development. Human Genet Embryol 5:e111. doi: 10.4172/2161-0436.1000e111
Copyright: © 2015 Souza-Pardo APD. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Recently, I had in my hands an interesting and highly recommended review from Jueng Soo You and Peter Jones entitled “Cancer Genetics and Epigenetics: Two Sides of the Same Coin?” which was published in Cancer Cell. In this review, the authors discuss the role and the weight of genetics and epigenetics in tumorigenesis. According to them “intriguing evidences have emerged showing that genetic and epigenetic mechanism are not separate events in cancer” and “alterations in epigenetic mechanisms can lead to genetic mutations, and genetic mutations in epigenetic regulators lead to an altered epigenome”. Here, I develop this theme based on this last statement.