Signaling Pathways that Facilitate Chronic Inflammation-Induced CarcinogenesisXiaomei Hou1, Fan Yang1, Wenbin Liu1, Zhongxing Fu1, Lei Chen1, Zixiong Li1, Chong Ni1, Min Liu2 and Guangwen Cao1*
- *Corresponding Author:
- Guangwen Cao
Department of Epidemiology
Second Military Medical University
800 Xiangyin Rd
Shanghai 200433, P.R. China
E-mail: [email protected]; [email protected]
Received date: October 05, 2015 Accepted date: October 06, 2015 Published date: October 09, 2015
Citation: Hou X, Yang F, Liu W, Fu Z, Chen L, et al. (2015) Signaling Pathways that Facilitate Chronic Inflammation-Induced Carcinogenesis. J Cell Signal 1:104. doi:10.4172/jcs.1000104
Copyright: © 2015 Hou X, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Recently, growing evidences have shown that chronic inflammation is the major cause of carcinogenesis. Inflammation signaling pathways can facilitate evolution and development of cancers in a variety of aspects, such as proliferation, metastasis, and apoptosis, etc. Nuclear factor-kappa B (NF-κB), janus-activated kinase (JAK)-signal transducers and activators 3 (STAT3), mitogen-activated protein kinase (MAPK), phosphatidylinositol-3-kinase/ protein kinase B (PKB, also known as Akt)/ mammalian target of rapamycin (PI3K/Akt/mTOR), Wnt/ β-catenin, and transforming growth factor (TGF)-β/Smad signaling pathways have been well studied, which are implicated in inflammation-induced carcinogenesis. Although tremendous of researches have reported these signaling pathways, few has explained the mechanism by which inflammation signaling pathways sustain activation during carcinogenesis. In this review, we summarized the present knowledge of 6 well known inflammation signaling pathways, especially their roles in chronic inflammation-induced carcinogenesis, reasons for the persistent inflammation, and potential inhibitors targeting key molecules for cancer therapy. This review will help in improving our understandings of how these inflammation signaling pathways take part in carcinogenesis, thus paving the way for the prediction of occurrence and prognosis as well as targeting therapy of cancers.