alexa Significance of Bitter Leaf (Vernonia Amagdalina) In Tropical Diseases and Beyond: A Review | OMICS International | Abstract
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Malaria Control & Elimination
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Research Article

Significance of Bitter Leaf (Vernonia Amagdalina) In Tropical Diseases and Beyond: A Review

Clement Egharevba1, Erharuyi Osayemwenre2, Vincent Imieje2, Joy Ahomafor3, Christopher Akunyuli2, Anthony Adeyanju Udu-Cosi2, Onyekaba Theophilus3, Osakue James4, Iftikhar Ali5 and Abiodun Falodun6*

1Department of Pharmacognosy, Faculty of Pharmacy, University of Benin, Nigeria

2Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Benin, Nigeria

3Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Delta State University, Abraka, Delta State, Nigeria

4Department of Physiology, School of Basic Medical Sciences, University of Benin, Benin City, Nigeria

5Institute of Chemistry, University of Rostock, Albert-Einstein-Str. 3A, 18059 Rostock, Germany

6Department of Pharmacognosy, School of Pharmacy, University of Mississippi, 38655 Oxford, Mississippi, USA

*Corresponding Author:
Abiodun Falodun
Department of Pharmacognosy
School of Pharmacy, University of Mississippi
38655 Oxford, Mississippi, USA
Tel: 662-638-5786, +2348073184488
E-mail: [email protected]

Received Date: April 04, 2014; Accepted Date: June 3, 2014; Published Date: June 10, 2014

Citation: Clement E, Erharuyi O, Vincent I, Joy A, Christopher A, et al. (2014) Significance of Bitter Leaf (Vernonia Amagdalina) In Tropical Diseases and Beyond: A Review. Malar Chemoth Cont 3:120. doi:10.4172/2090-2778.1000120

Copyright: © 2014 Clement E et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Vernonia amygdalina Delile (VA), family Asteraceae or Compositae is plants that is consumed locally as food and serve important ethnomedicinal uses. It grows throughout tropical Africa to a height of about 1 – 5 metres and it is indigenous to many West African Countries. Many parts of the plants are useful, they are used locally for the treatment of fever, Stomach disorder, jaundice, worm infestation, constipation, malaria, hiccups, kidney problems, amoebic dysentery, schistosomiasis, cough, wounds, diabetes, laxative, veneral diseases and other bacterial and protozoal infection. This review examines, discusses and summarizes the current evidence of ethnomedicinal uses, phytochemistry and biological activities as well as toxicity of this species with a view to identifying its therapeutic relations and possible contradictions, inconsistencies and gaps that may have arisen in the research literature. This review is based on literature study on journals and books of scientific origin from library, both manual and electronic sources such as PubMed, Science Direct, Elsevier, ACS, google Scholar etc using various combinations of search words. V. amagdalina is a tropical plant with a lot of interesting biological and medicinal uses. The plants are relatively not toxic, safe for consumption and possess a great potential as pharmaceutical leads for the treatment of diseases and beyond. This review will stimulate further research in the pharmacology and phytochemistry of V. amagdalina.


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