alexa Significance of De novo Donor-Specific Anti-HLA Antibodies in Renal Transplantation: A Single Center Experience
ISSN: 1747-0862

Journal of Molecular and Genetic Medicine
Open Access

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Short Communication

Significance of De novo Donor-Specific Anti-HLA Antibodies in Renal Transplantation: A Single Center Experience

Kozaki K1,2*, Adachi N1, Sasaki T1, Okada A1, Kato T1, Yuzawa K2, Inadome Y3 and Terashima T1

1Department of Surgery and Transplantation Surgery, National Hospital Organization, Mito Medical Center, 280 Sakuranosato, Ibaraki-Machi, Higashiibaraki-gun, Ibaraki, 311-3193, Japan

2Department of Transplantation Surgery, National Hospital Organization, Mito Medical Center, 280 Sakuranosato, Ibaraki-Machi, Higashiibaraki-gun, Ibaraki, 311-3193, Japan

3Department of Pathology, National Hospital Organization, Mito Medical Center, 280 Sakuranosato, Ibaraki-Machi, Higashiibaraki-gun, Ibaraki, 311-3193, Japan

*Corresponding Author:
Dr. Koichi Kozaki
Department of Surgery and Transplantation Surgery, National Hospital Organization, Mito Medical Center, 280 Sakuranosato, Ibaraki-Machi, Higashiibaraki-gun, Ibaraki, 311-3193, Japan
Tel: 81292407711
Fax: 81292407788
E-mail: [email protected]

Received Date: March 25, 2017; Accepted Date: March 29, 2017; Published Date: March 31, 2017

Citation: Kozaki K, Adachi N, Sasaki T, Okada A, Kato T, et al. (2017) Significance of de novo Donor-Specific Anti-HLA Antibodies in Renal Transplantation: A Single Center Experience. J Mol Genet Med 11:255 doi: 10.4172/1747-0862.1000255

Copyright: © 2017 Kozaki K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

 

Abstract

T cell-mediated rejection (TCMR) became controllable, and the long-term renal graft survival came to be obtained by the recent progress and innovation of the immuno-suppressants. Whereas the prophylaxis and control of antibody-mediated rejection (ABMR) caused by donor-specific anti-HLA antibody (DSA) are still insufficient and affect the long-term renal graft survival. DSA was classified roughly as follows: preexisting DSA existed in the patients before renal transplantation (RTx), and de novo DSA produced in the patients after RTx. There are many reports about the effect that preexisting DSA gives to a renal graft, and the treatment for ABMR with preexisting DSA is established to some degree. In contrast to preexisting DSA, it cannot be said that de novo DSA are considered enough at present. In this study, we examined the impact that de novo DSA gave to a renal graft in 40 RTx patients under treatment in our hospital. Although there was no significant difference as to the renal graft function in DSA positive and negative group, the renal graft survival showed the tendency that was better in a DSA negative group than a positive group (85% vs. 55%, P=0.0553). We perform monitoring of the de novo DSA positively and should contribute to the prognosis improvement of the renal graft in future.

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