alexa Significance of Interviral Recombination as Novel Mecha
ISSN: 2168-975X

Brain Disorders & Therapy
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Significance of Interviral Recombination as Novel Mechanism for Extending Viral Disease Repertoire

Edward M Johnson* and Dianne C Daniel

Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA 23507, USA

*Corresponding Author:
Edward M Johnson
PhD, Department of Microbiology and Molecular Cell Biology
Eastern Virginia Medical School, 700 West Olney Road
Norfolk, VA 23507
Tel: 757-375-1245
Fax: 757-624-2255
E-mail: [email protected]

Received date: May 26, 2016; Accepted date: June 20, 2016; Published date: June 23, 2016

Citation: Johnson EM, Daniel DC (2016) Significance of Interviral Recombination as a Novel Mechanism for Extending Viral Disease Repertoire. Brain Disord Ther 5:217. doi:10.4172/2168-975X.1000217

Copyright: © 2016 Johnson EM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



The recent observation of interviral recombination between members of two distinct classes of DNA viruses has opened the gates to a new field of human disease development. In all cases studied thus far interviral recombination is a rare event that requires special circumstances for intracellular interaction of participating viral genomes. The rarity and special requirements do not detract from the potential clinical significance of resulting recombinants, as exemplified by recombination between JC viral and Epstein-Barr viral genomes. This significance depends largely upon the mechanisms of recombination that would generate specific forms of recombinant viral genomes. At this time little is known regarding mechanisms of interviral recombination. DNA break-induced replication seems presently to be a highly plausible means of initiating formation of different, potentially active recombination products. Generalizing interviral recombination to a variety of viruses will open a fertile field for discovery as multiple diseases of mysterious etiology are investigated.


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