Significance of Macrophage Migration Inhibitory Factor (MIF) and Anti P 53 Antibodies in Prognosis of Hepatocellular Carcinoma
- *Corresponding Author:
- Lamiss Mohamed Abd Elaziz Sad, MD
Tanta University Hospital, Egypt
E-mail: [email protected]
Received Date: July 30, 2014; Accepted Date: September 24, 2014; Published Date: September 26, 2014
Citation: Sad LAA, Younis SG, Nagi HM (2014) Significance of Macrophage Migration Inhibitory Factor (MIF) and Anti P 53 Antibodiesin Prognosis of Hepatocellular Carcinoma. J Mol Biomark Diagn 5:192. doi:10.4172/2155-9929.1000192
Copyright: © 2014 Sad LM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background and aim: Prognosis of hepatocellular carcinoma (HCC) is very poor and determining the prognosis rely many factors and we aim at defining the prognostic factor of macrophage migration inhibitory factor (MIF) , anti P53 and its correlation with other prognostic factors in HCC.
Patients: Serum macrophage migration inhibitory factor and anti-p53 antibodies were measured in139 patients diagnosed with HCC using a specific enzyme-linked immunosorbent assay (ELISA) kit. The clinicopathological characteristics of the patients were compared with respect to the presence of serum anti-p53 antibodies.
Results: In univariate analysis, the prognostic factors of overall survival with statistical significance were portal vein thrombosis, total serum bilirubin, serum albumin, serum AST, serum ALT, Prothrombin time, viral marker and anti p53 antibody and MIF and on multivariate analysis the prognostic factors were BCLC staging, presence of extrahepatic metastases, the patient received treatment or not, anti p53 antibody and MIF.
Conclusion: Both MIF and Anti p53 antibody are associated with poor prognosis in HCC and it increased the prognostic potential of alpha fetoprotein.