alexa Significance of Screening the General Population for Potential Cardiovascular Diseases with a Combination Assay of B-type Natriuretic Peptide and High Sensitive Troponin I
ISSN: 2168-9784

Journal of Medical Diagnostic Methods
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Significance of Screening the General Population for Potential Cardiovascular Diseases with a Combination Assay of B-type Natriuretic Peptide and High Sensitive Troponin I

Satoshi Sugawa*

Abbott Japan Co, Ltd, Diagnostics Division, Japan

*Corresponding Author:
Satoshi Sugawa
Abbott Japan Co, Ltd, Diagnostics Division, 3-5-27, Mita
Minato-ku, Tokyo, 108-6305, Japan
Tel: +81345551104
Fax: +81334576735
E-mail: [email protected]

Received date: April 18, 2017; Accepted date: May 02, 2017; Published date: May 08, 2017

Citation: Satoshi S (2017) Significance of Screening the General Population for Potential Cardiovascular Diseases with a Combination Assay of B-type Natriuretic Peptide and High Sensitive Troponin I. J Med Diagn Meth 6:240. doi:10.4172/2168-9784.1000240

Copyright: © 2017 Sathoshi S. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Objectives: With increasing number of deaths by cardiovascular diseases, to develop an efficient method to screen the general population, such as a screening using biomarkers, for potential cardiovascular diseases is essential. We assessed the effectiveness of a combination assay of B-type natriuretic peptide (BNP) and cardiac troponin I (TnI) in detecting individuals with high cardiovascular risks.

Methods: BNP and TnI were determined using Abbott Architect immunoassays in 950 subjects who visited Takeda Hospital Medical Examination Center for the annual health check.

Results: The BNP level and TnI level were independently and positively associated with the Framingham Risk Score (FRS). The presence of hypertension, and CKD were positively, but that of dyslipidemia was negatively associated with the BNP level, while the presence of hypertension and dyslipidemia were positively associated with the TnI level. In a BNP-TnI plot where BNP is in the X-axis and TnI was in the Y-axis, we categorized the subjects into quadrants with the BNP cut-off (40.0 pg/ml) and the TnI cut-off (26.2 pg/ml); quadrant A (upper left), quadrant B (lower left), quadrant C (lower right) and quadrant D (upper right). In quadrants A, B, C and D, the number of subjects were 9, 932, 9 and 0, respectively. By assessing the differences between pairs of quadrants among quadrant A, B and C in terms of age, body mass index (BMI), systolic blood pressure (SBP), heart rate (HR), cardiothoracic ratio (CTR), vital capacity (VC), haemoglobin (Hb), platelet count (PLT), uric acid (UA), estimated glomerular filtration rate (eGFR), blood urea nitrogen (BUN), low-density lipoprotein cholesterol (LDL-C), highdensity lipoprotein cholesterol (HDL-C), triglyceride (TG), hemoglobin A1c (HbA1c) and fasting blood glucose (FBG) and the FRS, BMI, CTR and the FRS were higher in quadrants A than quadrant B while age, CTR, PLT and the FRS were higher in quadrants C than quadrant B. The factors that differentiated quadrants A and C were age, BMI and TG.

Conclusion: We conclude that not only BNP but also TnI could provide important information for cardiovascular risks in the general population due to its ability to detect the different high risk population as BNP could detect.


Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version