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ISSN: 2153-0602

Journal of Data Mining in Genomics & Proteomics
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Review Article

Significances of OMV and Extracellular Vesicle Proteomics

Tiwari V*, Solanki V, Roy R, Biswas D and Tiwari M

Department of Biochemistry, Central University of Rajasthan, Ajmer, Rajasthan, 305817, India

*Corresponding Author:
Tiwari V
Department of Biochemistry, Central University of Rajasthan
Ajmer, Rajasthan, 305817, India
Tel: +91-1463-238652
Fax: +91-1463-238722
E-mail: [email protected]

Received date: October 30, 2016; Accepted date: November 28, 2016; Published date: December 05, 2016

Citation: Tiwari V, Solanki V, Roy R, Biswas D, Tiwari M (2017) Significances of OMV and Extracellular Vesicle Proteomics . J Data Mining Genomics Proteomics 8:208. doi: 10.4172/2153-0602.1000208

Copyright: © 2016 Tiwari V, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Outer Membrane Vesicle (OMV) proteome has been involved into the pathogenesis of diseases and resistance of microorganisms against a number of antibiotics, mechanism of action of probiotics and host-pathogen interaction etc. We have enlightened the role played by extracellular vesicles proteomics in the pathogenesis of different diseases related to human. Isolation succeeded by purification of ample amount of OMV from biological samples, is one of the most important steps for further proteome related analysis. With the development of both labelled and label-free methods used in proteomics, significant progress has been made in previous years in membrane proteomics. Hence, it is important to review the biological significance of proteins found in the OMV fractions using membrane proteomics approach. We have also explained methods used for isolation, purification and quantification of OMV. In the present review, it can be concluded that proteomic study of outer membrane and extracellular vesicles has now gained priority for the detailed study of disease pathogenesis, drug resistance, vaccine development, cell signalling etc.

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