alexa Simvastatin-Induced Pleuro-Pericardial Effusion and Meg
ISSN: 2329-9126

Journal of General Practice
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Case Report

Simvastatin-Induced Pleuro-Pericardial Effusion and Megaloblastic Anemia

Ali A. Alzu'bi*
Internal Medicine Department, King Hussein Medical City, Royal Medical Services, Jordan
Corresponding Author : Ali A. Alzu'bi
Internal Medicine Department
King Hussein Medical City
Royal Medical Services
Jordan
E-mail: [email protected]
Received: July 27 2015 Accepted: August 19 2015 Published: August 20 2015
Citation:Alzu'bi AA (2015) Simvastatin-Induced Pleuro-Pericardial Effusion and Megaloblastic Anemia. J Gen Practice 3:198. doi:10.4172/2329-9126.1000198
Copyright: ©2015 Alzu’bi AA. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Statins competitively inhibit 3-hyroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, an enzyme involved in cholesterol synthesis, especially in the liver. Statins are considered for all patients with cardiovascular diseases such as coronary heart disease, peripheral vascular disease, non-haemorrhagic stroke, and transient ischemic attacks. Pleural and pericardial effusions may be caused by infectious diseases, malignancies and autoimmune disorders. However, unexplained effusions should raise the possibility of drugs as being the cause. Drug-induced anemia may be in the form of auto-immune or oxidative hemolysis, aplastic anemia, sideroblastic anemia or megaloblastic anemia. I report a case of lymphocytic pleural effusion, pericardial effusion and megaloblastic anemia in a patient known to have ischemic stroke, diabetes mellitus and hypertension. In the view of un-yielding clinical and laboratory evaluation, a drug-induced reaction was suspected. Because of the recent addition of simvastatin to the patient's regimen, the improvement of the patient's condition after discontinuation of simvastatin and recurrence of symptoms following it's re-administration, a conclusion was made that simvastatin may be the cause of the patient's clinical picture and should be further considered as a cause of unexplained pleural and pericardial effusions, and megaloblastic anemia.

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