alexa Single and Multiple Pharmacokinetics of Enrofloxacin and Ciprofloxacin in Pigs
ISSN: 0975-0851

Journal of Bioequivalence & Bioavailability
Open Access

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Research Article

Single and Multiple Pharmacokinetics of Enrofloxacin and Ciprofloxacin in Pigs

Claudio Araneda1*, Paulina Villar1, Carolina Cuadros1, Mauricio del Valle1, Pia Nunes2 and Margarita Santelices2

1Department of Pharmaceutical Research & Development, Centrovet Ltd, Los Cerrillos 602, Santiago, Chile

2Department of Regulatory Affairs, Centrovet Ltd, Los Cerrillos 602, Santiago, Chile

*Corresponding Author:
Claudio Araneda
Department of Pharmaceutical Research & Development
Centrovet Ltd, Los Cerrillos 602, Santiago, Chile
Tel: +5625837700
Fax: +5625837701
E-mail: [email protected]

Received Date: November 08, 2012; Accepted Date: December 17, 2012; Published Date: December 19, 2012

Citation: Araneda C, Villar P, Cuadros C, del Valle M, Nunes P, et al. (2013) Single and Multiple Pharmacokinetics of Enrofloxacin and Ciprofloxacin in Pigs. J Bioequiv Availab 5: 041-046. doi: 10.4172/jbb.1000132

Copyright: © 2013 Araneda C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Pharmacokinetics of Enrofloxacin (ENR) and Ciprofloxacin (CPX) in pig plasma was studied by HPLC-FL analysis using two injectable solutions, Enromic ® 20% (single dose of 7.5 mg ENR Kg -1 body weight) and Enromic ® 10% (multiple dose of 2.5 mg ENR Kg -1 body weight/day during 3 consecutive days). For the method validation, standard calibration curves were prepared between 0.025 and 0.5 μg mL -1 , with r 2 >0.9998 for both analytes. Quantification limits were 0.0282 and 0.0289 μg mL -1 for ENR y CPX, respectively; recovery percentages vary between 90.09% and 104.84% for ENR, and 63.01% and 89.01% for CPX, and precision obtained for measurements made on different days, expressed as %RSD, varied between 2.70% and 15.26% for ENR, and between 6.58% and 13.31% for CPX. Pharmacokinetic parameters gave values for Enromic ® 20% of 1.139 ± 0.320 μg mL -1 (C max ), 3.500 ± 1.581 h (T max ) and 17.821 ± 3.020 μg mL -1 h (AUC 0→∞ ) DU for ENR and 0.047 ± 0.010 μg mL -1 (C max ), 9.200 ± 1.932 h (T max ) and 1.027 ± 0.138 μg mL -1 h (AUC 0→∞ ) for CPX . For the product Enromic ® 10% (multiple doses), values were 0.428 ± 0.119 μg mL -1 (C max ), 5.000 ± 0 h (T max ) and 4.616 ± 1.138 μg mL -1 h (AUC 0→∞ ) for ENR and for CPX were 0.023 ± 0.006 μg mL -1 (C max ), 6.000 ± 2.108 h (T max ) and 0.424 ± 0.129 μg mL -1 h (AUC 0→∞ ) . We conclude that the most analyzed parameters are similar for both products, regardless of their different administration regime.

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