Single Fraction Compared with Multiple Fraction Re-Irradiations in Patients with Painful Bone Metastases
Mona M Sayed, Mostafa E Abdel-Wanis and Mohamed I El-Sayed*
Radiation Therapy Department, South Egypt Cancer Institute, Assiut University, Egypt
- *Corresponding Author:
- Mohamed I. El-sayed, MD
Department of Radiation Oncology
South Egypt Cancer Institute
Assiut University, Assiut
Egypt, Zip code: 71111
Tel: (0020) 1222953887
Fax: (0020) 882348609
E-mail: [email protected]
Received date: December 27, 2012; Accepted date: January 28, 2013; Published date: January 30, 2013
Citation: Sayed MM, Abdel-Wanis ME, El-Sayed MI (2013) Single Fraction Compared with Multiple Fraction Re-Irradiations in Patients with Painful Bone Metastases. J Cancer Sci Ther 5:089-093. doi:10.4172/1948-5956.1000190
Copyright: © 2013 Sayed MM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Objectives: Patients with painful bone metastasis treated with palliative radiation therapy (RTH) may require
re-irradiation. This work aims at assessing the efficacy and safety of re-irradiation for painful bone metastases using
single 8 Gy fractions versus (4 Gy × 5 fractions).
Methods: From June 2011 to December 2012, previously irradiated bone metastases were re-irradiated with
single 8 Gy fractions (group I) or, 4 Gy × 5 fractions (group II). Pain management index (PMI) was determined.
Pearson’s r correlation coefficient was calculated between negative PMI at presentation and age, ECOG
Performance Status, sex, and primary cancer site.
Results: Two months after RTH, about one fifth of patients achieved no pain, mild pain in 75.5% of the
remaining patients and no patient suffered from severe pain. There was no significant difference (p>0.05) between
groups (I and II) regarding pain relief. Negative PMI score, was reduced to from 37% at presentation to 25%, at 2
months follow up. A strong negative association between PMI and performance status (p=0.0057, 95% confidence
interval between 0.109 and 0.557) was found.
Conclusion: Palliative re-irradiation with either single 8 Gy fraction or with, 4 Gy × 5 fractions was effective
and safe in pain relief.