Single Polymer-drug Conjugate Carrying Two Drugs for Fixed-dose CodeliveryYan Li, Haiqing Dong, Xuequan Li, Donglu Shi and Yongyong Li*
Shanghai East Hospital, The Institute for Biomedical Engineering and Nano Science (iNANO), Tongji University School of Medicine, Shanghai, P.R.China
- *Corresponding Author:
- Yongyong Li
Shanghai East Hospital
The Institute for Biomedical Engineering and Nano Science (iNANO)
Tongji University School of Medicine
E-mail: [email protected]
Received date: July 29, 2014; Accepted date: September 21, 2014; Published date: September 24, 2014
Citation: Li Y, Dong H, Li X, Shi D, Li Y (2014) Single Polymer-drug Conjugate Carrying Two Drugs for Fixed-dose Codelivery. Med chem 4:672-683. doi:10.4172/2161-0444.1000211
Copyright: 2014 Li Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Fixed-dose combination chemotherapy holds great potential for management of cancer. Thus a drug delivery system which can administer a controlled ratio of several drugs simultaneously and control the drug release at the cancer site is highly desired. In this work, a fixed-dose dual drug loaded polymer micelle is formed by the self-assembly of a single polymer–drug conjugate carrying a combination of drugs. A predetermined ratio of the two drugs can be obtained via a facile and efficient solid-phase synthesis method. MTT assay demonstrated that the polymer micelles are more effective in altering the proliferation rate of MCF-7 tumor cells due to its higher solubility than free drugs. Furthermore, the introduction of the redox-sensitive disulfide linker between the hydrophilic PEG and the hydrophobic drugs facilitates drug release in tumor cellular redox environment and thus enhances the therapeutic effectiveness dramatically.