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Review Article

Single-Cell Metabolomics by Mass Spectrometry for Drug Discovery: Moving Forward

Nassar SF1*, Wisnewski AV2, Wu T3 and Raddassi K1

1Yale School of Medicine, Department of Neurology, New Haven, CT 06511, USA

2School of Medicine, Department of Internal Medicine, Yale University, New Haven, CT, USA

3West Campus Analytical Core, Yale University, West Haven, CT, USA

Corresponding Author:
Nassar SF
Yale School of Medicine
Department of Neurology, New Haven
CT 06511, USA
Tel: 2038099608
E-mail: [email protected]

Received date: July 05, 2017; Accepted date: July 25, 2017; Published date: July 31, 2017

Citation: Nassar SF, Wisnewski AV, Wu T, Raddassi K (2017) Single-Cell Metabolomics by Mass Spectrometry for Drug Discovery: Moving Forward. Drug Des 6:149. doi:10.4172/2169-0138.1000149

Copyright: © 2017 Nassar SF, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Abstract

Metabolomics is one omics approach that can be used to acquire comprehensive information on the composition of a metabolite pool to provide a functional screen of the cellular state. Single-cell metabolomics is proving useful at the molecular level for major biological research in drug development. One of the main goals of single-cell metabolomics research is to gain knowledge of cellular interaction with and in response to environmental influences on a molecular level, through a comprehensive understanding of cellular functions. In this short review, we discuss the importance of single-cell metabolomics, the concentrations of metabolites in cells, single-cell isolation, analytical methodologies for single-cell metabolomics, future prospects and a possible strategy for studying single-cell metabolomics by combining Fluorescence-activated cell sorting (FACS), Cytometry by time-of-flight (CyTOF) and Liquid Chromatography with tandem mass spectrometry (LC-MS/MS).

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