alexa SIRT1, IGFBP-3 and CAV1 Promoter DNA Methylation in Aging
ISSN: 2161-1025

Translational Medicine
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

SIRT1, IGFBP-3 and CAV1 Promoter DNA Methylation in Aging

Carolina Oliveira Gigek1*, Luara Carolina Frias Lisboa1, Patricia Natalia Oliveira Silva1, Mariana Ferreira Leal1, Roger W de Labio2, Spencer Luiz Marques Payão2 and Marilia de Arruda Cardoso Smith1

1Discipline of Genetics, Department of Morphology and Genetics, Federal University of São Paulo, SP, Brazil

2Laboratory of Genetics, Blood Center, Faculty of Medicine of Marilia (FAMEMA), Marilia, SP, Brazil

*Corresponding Author:
Carolina de Oliveira Gigek
Paulista School of Medicine
Federal University of Sao Paulo
(UNIFESP)Rua Botucatu 740, Ed Leitao da Cunha
04023-900, Sao Paulo - SP – Brazil
Tel: 55 (11) 55764260
Fax: 55 (11) 55764264
E-mail: [email protected]

Received Date: May 16, 2014; Accepted Date: June 27, 2014; Published Date: July 01, 2014

Citation: Gigek CO, Lisboa LCF, Silva PNO, Leal MF, de Labio RW, et al. (2014) SIRT1, IGFBP-3 and CAV1 Promoter DNA Methylation in Aging . Transl Med (Sunnyvale) 4:133. doi:10.4172/2161-1025.1000133

Copyright: © 2014 Gigek CO, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

The human genome is a fragile and highly conserved structure that accumulates a wide range of damaging alterations with age. Long-term alterations in the transcriptional potential of a cell are heritable and these changes are called epigenetics. The most studied alteration is the DNA methylation, which can regulate gene expression, often blocking gene transcription. The relationship between epigenetics and aging was proposed many years ago, and a decrease in the genomic global DNA methylation with age was largely observed. In this study we describe the methylation status of SIRT1, IGFBP-3 and CAV1 in a young and an older group of healthy individuals by methylation-specific PCR. SIRT1and IGFBP-3 promoter methylation frequency was significantly higher in the older than in the young adult group. Moreover, when combining promoter methylation status of several genes we observed that the total number of methylated promoters more than 85% of older individuals presented 4 promoters against only 46% of young adults. These findings may suggest that with increasing age there is an epigenetic switching to gene repression. The understanding of age-related genes methylation status can lead to a better comprehension of the role of epigenetic variation in the aging process.

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords