alexa Sirt1-Independent Rescue of Muscle Regeneration by Resveratrol in Type I Diabetes | OMICS International | Abstract
ISSN: 2155-6156

Journal of Diabetes & Metabolism
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Research Article

Sirt1-Independent Rescue of Muscle Regeneration by Resveratrol in Type I Diabetes

Jaemin Jeong1,2*, Michael J. Conboy1 and Irina M. Conboy1*

1 Department of Bioengineering and QB3 Institute, University of California, USA

2 Division of Radiation Oncology, Korea institute of Radiological and Medical Sciences, South Korea

*Corresponding Authors:
Jaemin Jeong
Division of Radiation Caner Research
Korea Institute of Radiological & Medical Science
215-4 Gongneung-Dong, Nowon-Gu
Seoul, 139-706, South of Korea
Tel: +82-10-4712-5256
Fax: +82-2-970-2402
E-mail: [email protected]

Irina M. Conboy
174 Stanley Hall, Department of Bioengineering
University of California Berkeley
Berkeley, CA, USA
Tel: (510) 666-2792
Fax: (510) 642-5835
E-mail: [email protected]

Received date: July 18, 2013; Accepted date: September 11, 2013; Published date: September 17, 2013

Citation: Jeong J, Conboy MJ, Conboy IM (2013) Sirt1-Independent Rescue of Muscle Regeneration by Resveratrol in Type I Diabetes. J Diabetes Metab 4:289. doi: 10.4172/2155-6156.1000289

Copyright: © 2013 Jeong J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The loss of insulin producing pancreatic β-cells or peripheral resistance to insulin signaling causes diabetes mellitus, a terminal metabolic disorder that broadly affects organ systems ultimately leading to chronic wounds, blindness, muscle wasting and other disorders of abandoned tissue maintenance. We have recently demonstrated that in a mouse model of type I diabetes, there is a rapid decline in the regenerative capacity of muscle stem (satellite) cells due to elevated levels of myostatin; and that either insulin or inhibition of TGF-β receptor signaling rescues muscle repair in the diabetic condition. Resveratrol (RSV) has been shown to improve energy metabolism in cases of type II diabetes, but its effects on stem cells and tissue regeneration are not well understood in a diabetic organism in general or in type I diabetes in particular. In this work, we studied the effect of RSV on the enhancement of muscle regeneration in type I diabetes. Our data demonstrate that systemic delivery of RSV to severely diabetic mice with ablated pancreatic β-cells rescues muscle regeneration by boosting the myogenic capacity of muscle stem cells. Therefore, our results suggest that in our experimental system, RSV did not reduce the blood glucose levels (BGL) in diabetic animals and did not act through its key effector Sirt1 in the rescue of muscle regenerative capacity. Importantly, our data uncovers that muscle stem cells in diabetic animals have reduced mitochondrial membrane potential, which is restored to its healthy levels by RSV that does not act via Sirt1, based on the pharmacological and genetic data but that this boost of intracellular energy enables productive tissue repair, but RSV in an animal model of type I diabetes.

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