alexa Sitagliptin Suppresses Active Ghrelin in Patients with
ISSN: 2155-6156

Journal of Diabetes & Metabolism
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Sitagliptin Suppresses Active Ghrelin in Patients with Diabetes

Berhane Seyoum*, Alemu Fite and Abdul Abou-Samra

Division of Endocrinology, Diabetes and Metabolism, Wayne State University School of Medicine, Detroit, Michigan, USA

*Corresponding Author:
Berhane Seyoum, MD, MPH
Division of Endocrinology
Diabetes and Metabolism
Wayne State University School of Medicine
4201 St. Antoine, UHC-4H Detroit, MI 48201, USA
Tel: 313-595-2830
Fax: 313-993-0903
E-mail: [email protected]

Received date November 07, 2011; Accepted date December 04, 2011; Published date December 08, 2011

Citation: Seyoum B, Fite A, Abou-Samra A (2011) Sitagliptin Suppresses Active Ghrelin in Patients with Diabetes. J Diabetes Metab 2:157. doi:10.4172/2155-6156.1000157

Copyright: © 2011 Seyoum B, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Ghrelin is an appetite-stimulating hormone mainly produced by the stomach. Circulating levels of ghrelin increase in fasting sates and fall following meal. Sitagliptin is an orally available new class of anti-diabetic drug that inhibits dipeptidyl peptidase-4 (DPP-4) leading to 2-3 fold increase in the serum concentration of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). This study was performed to determine the effects of sitagliptin on circulating levels of ghrelin in control subjects (N=15) and diabetic patients (N=46). The diabetic patients were treated with sitagliptin (N=15), metformin (N=16) or combination of sitagliptin and metformin (N=15) for one week. Serum concentrations of total and active ghrelin were determined immediately before and 2 hours after meal challenge. The tests were repeated among patients with diabetes after receiving drug therapy for one week. Active ghrelin was significantly more suppressed than total ghrelin in diabetic patients (by 36%, p<0.001). In patients taking sitagliptin, total ghrelin (means±SEM) fell from 386±37 pg/ml at baseline to 345±73 pg/ml whereas active ghrelin decreased from 160±18 pg/ml to 85±12 pg/ml (p<0.01). There was no statistical difference in ghrelin levels between the three treatment groups. Active ghrelin concentration correlated negatively with BMI in diabetic patients (P<0.05). After adjusting data for sitagliptin or its combination with metformin suppressed active: total ghrelin ratio more potently than metformin alone (P<0.001). Sitagliptin suppressed active ghrelin more significantly in patients with diabetes when compared to healthy controls. Postprandial ghrelin suppression was strongest after medication. The result of this study warrants further investigation of the significance of ghrelin suppression in patients with diabetes.

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords