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ISSN: 2167-0277

Journal of Sleep Disorders & Therapy
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Research Article

Sleeping Pills and Quality of Wake Time: The Missing Link

Sohil A Khan1,2*, reasure M McGuire2-5 and Helen S Heussler2,6,7
1School of Pharmacy, Griffith University, Gold Coast, Australia
2Mater Research Institute, Mater Health Services, South Brisbane, Australia
3Mater Pharmacy Services, Mater Health Services, South Brisbane, Australia
4Faculty of Health Sciences and Medicine, Bond University, Gold Coast, Australia
5School of Pharmacy, The University of Queensland, Woolloongabba, Australia
6Deparrment of Respiratory and Sleep Medicine, Mater Children’s Hospital, Mater Health Services, South Brisbane, Australia
7School of Medicine, The University of Queensland, Herston, Australia
Corresponding Author : Sohil A Khan
School of Pharmacy, Griffith University
Gold Coast, Australia
Tel: +61 75552 7097
Fax: +61 75552 8804
E-mail: [email protected]
Received August 27, 2013; Accepted September 12, 2013; Published September 17 2013
Citation: Khan SA, McGuire TM, Heussler HS (2013) Sleeping Pills and Quality of Wake Time: The Missing Link. J Sleep Disord Ther 2: 138. doi:
Copyright: © 2013 Khan SA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: The rising incidence of insomnia in a 24/7 global society quantifies the burden for the individual, in terms of reduced quality of life (QOL), and for society at large, in terms of work absenteeism, disability, and health care costs. Aim: To evaluate research on hypnosedatives (benzodiazepines, non-benzodiazepines) and complementary medicines in paediatric insomnia where quality of wake time is one of the key efficacy outcomes. Design and setting: Retrospective data analysis of clinical studies in paediatric insomnia Methods: A systematic review of clinical studies of hypnosedatives and complementary medicines in paediatric insomnia was conducted. PubMed and Cochrane Central Register of Controlled Trials (January 2002- August 2013) were searched for studies in children aged 3 to18 years (male or female). Quality of wake time and/or health related QOL parameters were assessed as the outcomes. Results: From 31 potentially relevant studies, only one, involving melatonin, met the inclusion criteria. One hundred and forty six children (aged 3 to15 years 8 months) diagnosed with insomnia were evaluated in a 12 week double masked randomised placebo controlled phase III multi-centre trial. Child behaviour and family functioning showed some improvement and favoured use of melatonin but was not statistically significant. There were no controlled clinical studies evaluating the impact of benzodiazepines and non-benzodiazepines hypnosedatives on quality of wake time in the management of paediatric insomnia. Conclusion: Data on quality of wake time in children with insomnia are scarce. Research has focused on addressing the metrics of sleep, with quality of wake time notably ignored. QOL measurement provides valuable information about the psychological and social impact of treatment on children with insomnia. Complementary medicines such as melatonin appear to improve the quality of wake time in paediatric insomnia where there are comorbid conditions; but further research is needed.

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