alexa Small Cell Neuroendocrine Carcinoma of the Uterine Cervix to Analysis of 3 Cases
ISSN: 2165-7920

Journal of Clinical Case Reports
Open Access

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Case Report

Small Cell Neuroendocrine Carcinoma of the Uterine Cervix to Analysis of 3 Cases

Aurélie Pelissier-Komorek1,4*, Christian Garbar2, Véronique Dalstein3, Nicolas Gavillon1, Olivier Graesslin1 and Aude-Marie Savoye4
1Department of Gynecology Obstetric, University Hospital of Reims, France
2Department of Pathology, Jean Godinot Institut, avenue du Général Koenig, France
3Department of Pathology, University Hospital of Reims, France
4Department of Oncology, Jean Godinot Institut, avenue du Général Koenig, France
Corresponding Author : Aurélie Pelissier-Komorek
Department of Gynecology Obstetric
University Hospital of Reims
45 rue Cognacq Jay, 51100 Reims, France
Tel: +33-326789158
Fax: +33-326789047
E-mail: [email protected]
Received February 09, 2013; Accepted April 08, 2013; Published April 10, 2013
Citation: Pelissier-Komorek A, Garbar C, Dalstein V, Gavillon N, Graesslin O, et al. (2013) Small Cell Neuroendocrine Carcinoma of the Uterine Cervix to Analysis of 3 Cases. J Clin Case Rep 3:267. doi:10.4172/2165-7920.1000267
Copyright: © 2013 Pelissier-Komorek A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Background: Histopathologically similar to small cell carcinoma of lung, small cell neuroendocrine carcinoma of the cervix is a rare malignancy with an aggressive behavior, due to an early lymphatic involvement and hematogenous dissemination. Pelvic recurrence and distant metastasis are very common. In literature, the best treatment modality remains controversial. Cases: From a series of 3 cases and a literature review, we focus on screening, prognostic factors and treatment of this cancer. Conclusion: Human Papilloma Virus (HPV) 18 infection seems to be specifically related to small cell neuroendocrine carcinoma. Screening with HPV genotyping, and a multimodal therapy could improve the prognosis of these patients.

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