alexa Smoking Influences the Yield of Dendritic Cells for Cancer Immunotherapy
ISSN: 2167-7689

Pharmaceutical Regulatory Affairs: Open Access
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Research Article

Smoking Influences the Yield of Dendritic Cells for Cancer Immunotherapy

Shimodaira S1*, Higuchi Y1, Koya T1, Kobayashi T2, Yanagisawa R1, Hirabayashi K1, Ito K2,3, Koizumi T2, Maejima S4 and Udagawa N5

1Center for Advanced Cell Therapy, Shinshu University Hospital, Matsumoto, Japan

2Shinshu Cancer Center, Shinshu University Hospital, Matsumoto, Japan

3Department of Breast and Endocrine Surgery, Shinshu University Hospital, Matsumoto, Japan

4Internal Medicine, Matsumoto Dental University, Shiojiri, Japan

5Biochemistry, Matsumoto Dental University, Shiojiri, Japan

Corresponding Author:
Shigetaka Shimodaira
Center for Advanced Cell Therapy Shinshu University Hospital, 3-1-1 Asahi Matsumoto, Nagano 390-8621, Japan
Tel: +81-263-37-3580
Fax: +81-263-37-3027
E-mail: [email protected]

Received December 31, 2014; Accepted February 02, 2015; Published February 09, 2015

Citation: Shimodaira S, Higuchi Y, Koya T, Kobayashi T, Yanagisawa R, et al. (2015) Smoking Influences the Yield of Dendritic Cells for Cancer Immunotherapy. Pharmaceut Reg Affairs 4:133. doi: 10.4172/2167-7689.1000133

Copyright: © 2015 Shimodaira S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Background: Dendritic cell (DC)-based vaccination is considered to be a potentially effective therapeutic strategy against advanced cancer. The aim of this study was to address the smoking history that might affect the preparation of DC vaccines in validated instructional manufacture. Materials and Methods: Data on mature DCs generated from 102 sessions of leukapheresis performed on 92 patients with advanced cancer or sarcoma were retrospectively evaluated and compared in relation to the data between their smoking history and the generation of DCs from these patients. 61 patients with adenocarcinoma, including 7 with lung, 10 with breast, 8 with stomach, 12 with colorectal, and 23 with pancreatic adenocarcinoma were enrolled. Results: The average yield of autologous DCs (15.5 ± 8.3x107) was thought to be dependent on the number of monocytes (124.2 ± 74.1x107) collected by leukapheresis. The average ratio of DCs/apheresed monocytes (DC/aM ratio) was lower in the smoker group (11.1 ± 7.2%) than that in the non-smoker group (17.2 ± 9.3%, p=0.001). The number of DCs and the DC/aM ratio were lower in the patients with gastric and pancreatic cancer than in those with adenocarcinoma of other sites. Conclusions: As cancer therapy moves forward into the field of persona

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