alexa SN2-Palmitate Improves Crying and Sleep in Infants Fed
ISSN: 2090-7214

Clinics in Mother and Child Health
Open Access

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Research Article

SN2-Palmitate Improves Crying and Sleep in Infants Fed Formula with Prebiotics: A Double-Blind Randomized Clinical Trial

Fabiana Bar-Yoseph1*, Yael Lifshitz1, Tzafra Cohen1, Patrice Malard2, Zailing Li3, Hong Cui4, Aimin Zhang5, Jing-Lan Wu6 and Chundi Xu6

1Nutrition R&D, Enzymotec Ltd., Migdal HaEmeq, Israel

2R&D, Biostime, Guangzhou, China

3Department of Pediatrics, Peking University Third Hospital, Beijing, China

4Pediatric Ward, Beijing Friendship Hospital Affiliated with Capital University of Medical Science, Beijing, China

5Department of Pediatrics, The People's Hospital of Hunan Province, Changsha, China

6Department of Pediatrics, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China

*Corresponding Author:
Fabiana Bar-Yoseph
Nutrition R&D, Enzymotec Ltd
Migdal Haemeq, Israel
Tel: +972747177177
E-mail: [email protected]

Received Date: June 02, 2017; Accepted Date: June 15, 2017; Published Date: June 25, 2017

Citation: Bar-Yoseph F, Lifshitz Y, Cohen T, Malard P, Li Z, et al. (2017) SN2-Palmitate Improves Crying and Sleep in Infants Fed Formula with Prebiotics: A Double-Blind Randomized Clinical Trial. Clinics Mother Child Health 14:263. doi: 10.4172/2090-7214.1000263

Copyright: © 2017 Bar-Yoseph F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Background and Aim: Palmitic acid (PA, C16:0), one of the major saturated fatty acids in human milk fat being 17-25% of the fatty acids, is esterified mainly at the SN2-position (SN2-palmitate). Contrary in vegetable oils, which are commonly used as fat source in infant formulas, PA is esterified mainly at the outer positions, i.e, SN1 and SN3 positions, resulting in reduced fat absorption and harder stools. SN2-palmitate and prebiotics have been shown to improve digestion and reduce stool hardness. Our aim was to study the potential effects of SN2-palmitate in addition to prebiotics in formula-fed Chinese infants.

Methods: 171 healthy term infants were included (within 14 days from birth) in the study. Formula-fed infants were randomly assigned to receive either SN2-palmitate containing formula (INFAT®, Advanced Lipids), (n=57) or a Control formula (n=57). The two study formulas (Biostime, China) differed only in the ratio of PA at the SN2-position (43% vs. 13%). A similar group of breastfed infants (n=57) was included as a reference.

Results: The pattern of crying and sleep differed between the formula-fed groups. Fewer infants in the SN2 group cried at 12 weeks (23.2% vs. 45.5%, p<0.05); they had fewer crying episodes (2.0 vs. 3.6, at 6 weeks, p<0.05 and 1.0 vs. 2.2 at 12 weeks, p<0.02) and the duration of crying was lower (25.1 vs. 41.3 min at 6 weeks, p<0.05 and 11.2 vs. 21.2 min at 12 weeks, p<0.01) similar to the crying pattern of breastfed infants. Moreover, the infants in the SN2 group had longer daily sleep duration.

Conclusions: SN2-palmitate formula improves crying and sleeps patterns in addition to prebiotics in the first weeks of life. Thereby, SN2-palmitate improves the well-being of formula-fed infants and consequently the quality of life of their parents, further emphasizing the importance of SN2-palmitate for infant nutrition.

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