alexa Snake Venom Cytotoxins, Phospholipase A2s, and Zn2+-dep
ISSN: 2161-0495

Journal of Clinical Toxicology
Open Access

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Review Article

Snake Venom Cytotoxins, Phospholipase A2s, and Zn2+-dependent Metalloproteinases: Mechanisms of Action and Pharmacological Relevance

Sardar E Gasanov1,2, Ruben K Dagda3* and Eppie D Rael4

1Applied Mathematics and Informatics Department, Moscow State University Branch, 22 A. Timur Avenue, Tashkent 100060, Uzbekistan

2Science Department, Tashkent Ulugbek International School, 5-A J. Shoshiy Street, Tashkent 100100, Uzbekistan

3Pharmacology Department, University of Nevada School of Medicine, 1664 North Virginia St., Reno, NV 89557, USA

4Department of Biological Sciences, University of Texas at El Paso, 500 West University Avenue, El Paso, TX 79968, USA

*Corresponding Author:
Ruben K. Dagda
Assistant Professor
Pharmacology Department
University of Nevada School of Medicine
1664 N. Virginia St. Reno, NV 89557, USA
Tel: 775-784-4121
E-mail: [email protected]

Received date: December 24, 2013; Accepted date: January 21, 2014; Published date: January 26, 2014

Citation: Gasanov SE, Dagda RK, Rael ED (2013) Snake Venom Cytotoxins, Phospholipase A2s, and Zn2+-dependent Metalloproteinases: Mechanisms of Action and Pharmacological Relevance. J Clinic Toxicol 4:181. doi: 10.4172/2161-0495.1000181

Copyright: © 2014 Gasanov SE, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Snake venom toxins are responsible for causing severe pathology and toxicity following envenomation including necrosis, apoptosis, neurotoxicity, myotoxicity, cardiotoxicity, profuse hemorrhage, and disruption of blood homeostasis. Clinically, snake venom toxins therefore represent a significant hazard to snakebite victims which underscores the need to produce more efficient anti-venom. Some snake venom toxins, however, have great potential as drugs for treating human diseases. In this review, we discuss the biochemistry, structure/function, and pathology induced by snake venom toxins on human tissue. We provide a broad overview of cobra venom cytotoxins, catalytically active and inactive phospholipase A2s (PLA2s), and Zn2+-dependent metalloproteinases. We also propose biomedical applications whereby snake venom toxins can be employed for treating human diseases. Cobra venom cytotoxins, for example, may be utilized as anti-cancer agents since they are efficient at destroying certain types of cancer cells including leukemia. Additionally, increasing our understanding of the molecular mechanism(s) by which snake venom PLA2s promote hydrolysis of cell membrane phospholipids can give insight into the underlying biomedical implications for treating autoimmune disorders that are caused by dysregulated endogenous PLA2 activity. Lastly, we provide an exhaustive overview of snake venom Zn2+-dependent metalloproteinases and suggest ways by which these enzymes can be engineered for treating deep vein thrombosis and neurodegenerative disorders.

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