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ISSN: 2165-7092

Pancreatic Disorders & Therapy
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Review Article

Solid Pseudopapillary Neoplasms of the Pancreas: A Review

Katherine E Poruk, Christopher L Wolfgang and Matthew J Weiss*
Departments of Surgery, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Corresponding Author : Matthew J Weiss
MD, Department of Surgery
The Johns Hopkins University School of Medicine
Halsted 608, 600 N. Wolfe Street
Baltimore, MD 21287, USA
Tel: 4106143368
E-mail: [email protected]
Received September 23, 2014; Accepted October 28, 2014; Published November 02, 2014
Citation: Poruk KE, Wolfgang CL, Weiss MJ (2014) Solid Pseudopapillary Neoplasms of the Pancreas: A Review. Pancreat Disord Ther 4:143. doi:10.4172/2165-7092.1000143
Copyright: © 2014 Poruk KE, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Solid Pseudopapillary Neoplasms (SPN) of the pancreas is rare tumors found throughout the pancreas composed of solid and cystic components. Since their description by Frantz, SPNs have been shown to comprise 1-2% of pancreatic tumors. These neoplasms predominantly affect young females in the second and third decades of life. Little is known about the pathogenesis of these tumors, although there is suggestion of a neuroendocrine origin or relationship with sex hormone receptors. The mainstay of treatment continues to be surgical resection, even in patients who present with locally advanced or metastatic disease. SPNs have low malignant potential with 5-year survival estimated as high as 95%, including those with malignant disease. We aim to review the current understanding regarding the diagnosis, management, and outcomes of patients with solid pseudopapillary neoplasms of the pancreas.

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