alexa Soluble Receptor for Advanced Glycation End-products Le
ISSN: 2155-9880

Journal of Clinical & Experimental Cardiology
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Research Article

Soluble Receptor for Advanced Glycation End-products Levels in Chronic Heart Failure and Its Correlation to Left Ventricular Ejection Function

Colomba Falcone1-4*, Sara Bozzini1, Angela D’Angelo1,4, Maria Paola Buzzi1, Rossana Totaro1, Rossana Falcone1 and Gabriele Pelissero2,3
1Interdepartmental Center of Research in Molecular Medicine (CIRMC), University of Pavia, Pavia, Italy
2Department of Cardiology, Istituti Clinici di Pavia e Vigevano, University Hospital, Pavia, Italy
3IRCCS San Donato Hospital, Milano, Italy
4Department of Internal Medicine, University Hospital, Pavia, Italy
Corresponding Author : Colomba Falcone
Department of Cardiology
Istituiti Clinici di Pavia e Vigevano
University Hospital, Via Parco Vecchio 27, Pavia, Italy
Tel: +39 0382 433637
Fax: +39 0382 576821
E-mail: [email protected]
Received September 13, 2013; Accepted November 15, 2013; Published November 18, 2013
Citation: Falcone C, Bozzini S, D’Angelo A, Buzzi MP, Totaro R, et al. (2013) Soluble Receptor for Advanced Glycation End-products Levels in Chronic Heart Failure and Its Correlation to Left Ventricular Ejection Function. J Clin Exp Cardiolog 4:275. doi:10.4172/2155-9880.1000275
Copyright: © 2013 Falcone C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

The Receptor for Advanced Glycation End-products (RAGE), a multi-ligand member of the immunoglobulin superfamily, is a ubiquitous receptor present on epithelial, neuronal, vascular and inflammatory cells. AGEs have been implicated in vascular and myocardial dysfunction and in development of atherosclerosis but little are known about the role of the AGE-RAGE system in heart failure. The main objective of the study was to assess sRAGE plasma levels in patients with Chronic Heart Failure (CHF) focusing on patients with severe reduction of left ventricle function. We measured sRAGE plasma levels in 389 patients with CHF and 319 stable patients with Coronary Artery Disease (CAD). Patients with CHF had significantly lower values of soluble RAGE in respect to stable CAD population. The linear regression analysis showed that LVEF (Left Ventricularv Ejection Fraction) significantly correlated with sRAGE plasma concentrations; sRAGE plasma levels were significantly lower in patients with severe left ventricular systolic dysfunction compared with those with ejection Fraction ≥ 30%. Our data support a positive correlation between soluble RAGE plasma levels and left ventricular ejection fraction in the CHF population; we demonstrated that in subjects with CHF and severe left ventricular systolic dysfunction, soluble RAGE plasma concentrations were significantly lower in comparison with patients with moderate left ventricular dysfunction. This study suggests the possibility that soluble RAGE can be considered a new element to be used in prognostic stratification in patients affected by CHF.

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