Spectral Interrogation based SPR Sensor for Blood Glucose Detection with Improved Sensitivity and Stability
- *Corresponding Author:
- Srivastava SK
Department of Electro Optic Engineering
Ben Gurion University of the Negev
Beer Sheva-84105, Israel
E-mail: [email protected]
Received Date: March 23, 2015 Accepted Date: July 09, 2015 Published Date: July 19, 2015
Citation: Srivastava SK, Abdulhalim I (2015) Spectral Interrogation based SPR Sensor for blood Glucose Detection with Improved Sensitivity and Stability. J Biosens Bioelectron 6:172. doi: 10.4172/2155-6210.1000172
Copyright: © 2015 Srivastava SK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
A sensor chip for specific detection of blood glucose was developed. The sensor utilized a surface-plasmonresonance (SPR) setup on a prism based Kretschmann configuration utilizing spectral interrogation scheme. Selfassembled monolayers (SAMs) based preparation provided the chip stability due to covalent bonds and hence it can be reused for multiple times. Such a scheme can be advantageous in continuous monitoring of blood glucose, without changing the chip. Control experiments were performed without molecular recognition layer to confirm the performance of the sensor. Furthermore, the measurements were performed on blood serums and compared with that of a conventional glucometer. The present sensor has the advantages of improved sensitivity (0.14 nm/(mg/dl)) and stable response for 3 months, which are better compared to existing reports.