alexa Spectrophotometric Determination of Nicorandil in Bulk
ISSN: 1920-4159

Journal of Applied Pharmacy
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Spectrophotometric Determination of Nicorandil in Bulk and Pharmaceutical Formulation Using Phospho-Molybdenum Blue Complex

El-Adl SM1, El-Sadek ME1 and Saeed NM2*

1Department of Medicinal Chemistry, Zagazig University, Zagazig, Egypt

2Pharmacist, Ministry of Health, Egypt

*Corresponding Author:
Nariman M Saeed
Pharmacist
Ministry of Health, Egypt
Tel: (20-2) 7951821 / 794
E-mail: [email protected]

Received Date: May 03, 2017; Accepted Date: May 18, 2017; Published Date: May 25, 2017

Citation: El-Adl SM, El-Sadek ME, Saeed NM (2017) Spectrophotometric Determination of Nicorandil in Bulk and Pharmaceutical Formulation Using Phospho-Molybdenum Blue Complex. J Appl Pharm 9:243. doi: 10.21065/1920-4159.1000243

Copyright: © 2017 El-Adl SM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

A new spectrophotometric method is described for the determination of nicorandil in bulk and pharmaceutical dosage form. It is based on the reduction of nitrate in nicorandil to nitrite ion by using vanadium chloride, and reduction of phosphomolybdic acid to phospho-molybdenum blue complex by sodium sulfide, phospho-molybdenum blue complex is then oxidized by nitrite ion leading to a decrease in blue color intensity which found to be directly proportional to the concentration of nicorandil. Maximum absorbance was measured at 827 nm. Effect of acidity, volume of Sodium Sulfide, stability of complex, volume of vanadium chloride, time and temperature of the reaction were completely studied. The proposed method was satisfactorily applied for the determination of the drug in both bulk and pharmaceutical forms, the calibration curve was linear over the range (60–200 μg/ml) and the results were compared statistically with reference methods.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords