alexa Spectrophotometric Determination of Quinolones by Charge Transfer Complexation with Chloranilic Acid: Synthesis and Characterization | OMICS International | Abstract
ISSN: 2161-0444

Medicinal Chemistry
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Research Article

Spectrophotometric Determination of Quinolones by Charge Transfer Complexation with Chloranilic Acid: Synthesis and Characterization

Muhammad Saeed Arayne1, Najma Sultana2 and Saeeda Nadir Ali1*

1Department of Chemistry, University of Karachi, Karachi-75270, Pakistan

2Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan

*Corresponding Author:
Saeeda Nadir Ali
Department of Chemistry
University of Karachi
Karachi-75270, Pakistan
E-mail: [email protected]

Received date: June 21, 2013; Accepted date: September 16, 2013; Published date: September 18, 2013

Citation: Arayne MS, Sultana N, Ali SN (2013) Spectrophotometric Determination of Quinolones by Charge Transfer Complexation with Chloranilic Acid: Synthesis and Characterization. Med chem 3:271-275. doi:10.4172/2161-0444.1000150

Copyright: © 2013 Arayne MS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

A simple and sensitive spectrophotometric method has been described for the assay of quinolones in bulk drug and in pharmaceutical formulations. The developed method is based on the formation of colored charge transfer complexes of quinolones with chloranilic acid in acetonitrile solvent. The formed complexes absorbed at 417, 436, 419 and 436 nm for sparfloxacin, enoxacin, norfloxacin and levofloxacin respectively. Beer’s law is obeyed in the concentration range of 0.5-7, 1-10, 1-10 and 1-5 μg mL -1 with LLOD values 0.036, 0.0041, 0.0344 and 0.0063 ng mL -1 respectively. The data are discussed in terms of molar absorptivity, association constant and Gibb’s free energy. Spectral characteristics including oscillator’s strength, dipole moment, ionizationpotential, energy of complexes and resonance energy have been determined. Benesi-Hildebrand plots for each complex have been constructed. Structural characteristics of synthesized charge transfer complexes were determined by IR spectroscopy. The applicability of the method was demonstrated by determination of studied drugs in commercial tablets with satisfactory results. No interference from excipients was observed in the formulation

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