alexa Spectrum of Abnormal Movement in a Cohort of Neuro-Wils
ISSN: 2329-6895

Journal of Neurological Disorders
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Research Article

Spectrum of Abnormal Movement in a Cohort of Neuro-Wilson Patients with Radiological Associations

Moumita Bagchi1, Neelanjana Paul2, Soumitra Ghosh3, Suchitra Majumdar4, Santa Saha5, Arijit Roy6 and Shyamal K Das7*
1Department of Neurology, Columbia Asia Hospital, Kolkata, India
2Department of Psychiatry, I Care Medical College, Haldia, WB, India
3Department of Radiology Presently, Malda Medical College, Malda, WB, India
4Department of Ophthalmology, Institute of Post Graduate Medical Education and Research, Kolkata, India
5Department of Biochemistry, Bankura Medical College, Bankura, WB, India
6Department of Neurology, Bangur Institute of Neuroscience, and IPGMER, Kolkata, India
7Department of Neurology and Neurogenetics, Bangur Institute of Neuroscience and Institute of Post Graduate Medical education and Research, Kolkata, India
*Corresponding Author : Das SK
Professor and Head, Department of Neurology
and Neurogenetics, Bangur Institute of Neuroscience
and Institute of Post Graduate Medical Education
and Research, Kolkata, WB, India
Tel: 913322230003
E-mail: [email protected]
Received: December 07, 2015 Accepted: February 05, 2016 Published: February 08, 2016
Citation: Bagchi M, Paul N, Ghosh S, Majumdar S, Saha S, et al. (2016) Spectrum of Abnormal Movement in a Cohort of Neuro-Wilson Patients with Radiological Associations. J Neurol Disord 4:259. doi:10.4172/2329-6895.1000259
Copyright: © 2016 Bagchi M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Background: Disorders of movement are important features of Neuro-Wilson’s disease (NWD) and their recognition helps in early diagnosis. We studied the various types of movement disorders including any novel phenomenology found in our cohort of NWD, along with radiological correlations.

Method: A total of 129 consecutive patients of WD (M:F) were examined in Movement Disorders clinic of a tertiary care neurological institute at Kolkata, India. A semi-structured interview and examination determined the various types of movement disorders detected, after proper informed consent. Neuro-imaging (MRI of 1.5 Tesla system) was carried out whenever possible.

Results: The common movement disorders were dystonia (91.8%), Parkinsonism (83.72%), and tremor (53.49%). Others were movement induced focal myoclonus (12.4%), ataxia (11.63%), choreo-athetosis (15.5%). The less frequent movement disorders were akathisia (5.2%) and tics disorder (5.42%) and oromandibular dyskinesias (2.33%). MRI lesions were found to be associated with jaw opening dystonia (caudate), neck dystonia (putamen and pons), truncal dystonia (caudate, globus pallidus and cortical atrophy), appendicular dystonia (caudate and putamen), Parkinsonism (mid-brain), postural tremor (caudate and putamen), tics and akathisia (mid-brain and pons in both).

Conclusion: WD is associated with a variety of common movement disorders such as dystonia, Parkinsonism and tremor. The less frequent movement disorders were focal myoclonus, stereotypes, tics disorders and orofacial dyskinesia . Radiological lesions can be found in association with majority of the movement disorders except in few cases where functional imaging studies may help.


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