Spectrum of Systemic Yeast Infections in Leukemia Patients in Cameroon and Sensitivity of Isolates to Griseofulvin, Ketoconazole and Organic Extracts of Four Medicinal PlantsKenneth A Yongabi1,2* and Maureen Okeke2
- *Corresponding Author:
- Kenneth A Yongabi
Tropical Infectious Diseases and public Health Engineering Research Group (TIDPHERG)
Phytobiotechnology Research Foundation Institute, Catholic University of Cameroon (CATUC)
P.O.Box 921, Bamenda, Cameroon
Tel: +237 67566162
E-mail: [email protected]
Received date: October 19, 2015; Accepted date: November 02, 2015; Published date: November 12, 2015
Citation: Yongabi KA, Okeke M (2015) Spectrum of Systemic Yeast Infections in Leukemia Patients in Cameroon and Sensitivity of Isolates to Griseofulvin, Ketoconazole and Organic Extracts of Four Medicinal Plants . J Leuk 3:195. doi:10.4172/2329-6917.1000195
Copyright: © 2015 Yongabi KA. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Clinical management of leukemia patients with hydroxyurea - based chemotherapy drugs and radiotherapy often does not yield very quick therapeutic benefits in patients, especially in tropical resource limited countries. Evidence based supportive and palliative care plan is critical in the clinical management of leukemia patients, which clinicians and oncologists in Africa often do not adequately implement during in-patient management in hospitals for a number of reasons including cost and knowledge. The spectrum of opportunistic infections in leukemia conditions is not well known and considered during management plans. In this study, we report the spectrum of systemic yeast infections amongst leukemia patients attending Phytobiotechnology Research Foundation clinic in Cameroon from June 2012 to June 2015 for the presence of various opportunistic systemic mycoses. All the patients in this study were already receiving hydroxyurea therapy for more than one year at the hospitals in Cameroon. The screening and testing were done through visual observation, KOH microscopy, in addition to culture tests on potato and malt extract agars. Twenty patients screened, were found with systemic yeast infections. Culture of urine, mouth swabs, vaginal fluids and blood yielded a 80% isolates of Candida albicans, and 20% Non Albicans Candida (NAC) including Cryptococcus species isolated from oral swab only. The results generally show that systemic yeasts are prevalent in leukemia patients and its co morbidity may possibly complicate effective chemotherapy treatment. The anti-yeast activity of Persea americana, magnifera indica, Moringa oleifera, and Allium sativum was significant with zones of inhibitions exhibited by Moringa oleifera and Allium sativum showing a better ant yeast activities than with ketoconazole and griseofulvin. The results also suggested the need to exploit alternative botanicals in the comanagement of leukemia as well as its attending opportunistic infections is a critical step toward generating a better treatment for leukemia.