alexa Sperm DNA Fragmentation in Saudi Infertile Men with Normal Standard Semen Parameters
ISSN: 2167-0250

Andrology-Open Access
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Research Article

Sperm DNA Fragmentation in Saudi Infertile Men with Normal Standard Semen Parameters

Maher Hassan Al Ghedan1*, Hamoud Al Matrafi2, Hamad Al Sufyan3 and Mohamad Al-Tannir4
1Genetics Laboratory, Thuriah Medical Center Riyadh, Saudi Arabia
2Departments of Andrology & Urology Unit, Thuriah Medical Center, Riyadh, Saudi Arabia
3Department of Reproductive medicine, Thuriah Medical Center, Riyadh, Saudi Arabia
4Research Center, King Fahad Medical City, Riyadh, Saudi Arabia
*Corresponding Author : Maher Hassan Al Ghedan
Genetics laboratory, Thuriah Medical Center
P.O. Box 50246 Riyadh 11523, Saudi Arabia
Tel: 00966538334575
E-mail: [email protected]
Received November 17, 2014; Accepted January 23, 2015; Published February 02, 2015
Citation: Al Ghedan MH, Al Matrafi H, Al Sufyan H, Al-Tannir M (2015) Sperm DNA Fragmentation in Saudi Infertile Men with Normal Standard Semen Parameters. Andrology 4:126. doi:10.4172/2167-0250.1000126
Copyright: © 2015 Ghedan MHA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Almost 15% of infertile males have normal semen parameters and DNA Fragmentation Index (DFI) could be reasonably a valued tool for fertility extrapolation than the conventional semen analysis. To the best of our knowledge, this is the first study to assess the prevalence of high DFI in Saudi infertile men with normal standard semen parameters in order to support the generalizability about sperm DFI as a marker of male infertility. A total of 79 infertile men with normal semen standards were identified (study group). Standard semen analysis and sperm chromatin dispersion were carried out. 33 men (41.8% of the whole study group) had a DFI ≥ 20%; with 19 men (24.1%) (95% CI: 14.67-33.53) had a 20% ≤ DFI<30%, and 14 men (17.7 %) (95% CI: 9.28-26.12) had a DFI ≥ 30%. The mean DFI was 21.14% (±10.26%) with a median of 18.12% [5.09-57.23]. Our findings showed that a considerable proportion of men with normal semen parameters had high sperm DNA damage levels. Thus, the DFI by sperm chromatin dispersion test is essential to explain causes of infertility in cases where semen analysis has not shown any deviation from the norms.

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