alexa Sperm DNA Fragmentation is Significantly Increased in Those Men with Morphologically Abnormal Spermatozoa | OMICS International | Abstract
ISSN: 2375-4508

Journal of Fertilization: In Vitro - IVF-Worldwide, Reproductive Medicine, Genetics & Stem Cell Biology
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Research Article

Sperm DNA Fragmentation is Significantly Increased in Those Men with Morphologically Abnormal Spermatozoa

Javier García-Ferreyra1*, Lucy Villegas1, Rocío Romero Obst2, Patricia Zavala Obst2, Roly Hilario2, Giovanni Casafranca2 and Julio Dueñas-Chacón1,2
1FERTILAB Laboratory of Assisted Reproduction, Lima, Perú
2PROCREAR Fertility Center, Lima, Perú
*Corresponding Author : Javier García-Ferreyra Ph.D
FERTILAB Laboratory of Assisted Reproduction Av
San Felipe 1017, Lima 11, Perú
E-mail:[email protected]
Received July 15, 2014; Accepted August 14, 2014; Published August 16, 2014
Citation: García-Ferreyra J, Villegas L, Obst RR, Obst PZ, Hilario R, et al. (2014) Sperm DNA Fragmentation is Significantly Increased in Those Men with Morphologically Abnormal Spermatozoa. J Fertil In Vitro IVF Worldw Reprod Med Genet Stem Cell Biol 2:131. doi:10.4172/2375-4508.1000131
Copyright: © 2014 García-Ferreyra J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Purpose: To evaluate the levels of DNA fragmentation regarding to spermatozoa morphology in male infertility patients attending Andrology Laboratory at fertility center.  Methods: Semen samples of 196 patients were analyzed using computer-assisted semen analysis (CASA). Sperm DNA fragmentation was measured by the sperm chromatin dispersion test. According to the values of sperm morphology, the groups were conformed by teratozoospermic (105 patients) and normozoospermic (91 patients) men.  Results: Subjects’ ages ranged from 21 to 68 years. Teratozoospermic men were older that the normozoospermic men (39.72 ± 7.86 vs. 36.57 ± 6.29 years; P<0.05). Values of pH were similar in both evaluated groups (P:NS). Parameters of volume, concentration, motility and vitality in teratozoospermic men were significantly lower compared to those normozoospermic patients (P<0.05). High levels of DNA fragmentation were observed in those patients with abnormal sperm morphology compared to normozoospermic men (44.31 ± 7.52 vs. 34.92 ± 5.89; P<0.05).  Conclusions: Men with abnormal spermatozoa morphology showed high levels of DNA fragmentation. These significantly high percentages of sperm DNA damage will be an additional factor that drastically reduces the possibility of success in these infertile men.

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