Spina Bifida: Morphological Features, Molecular Regulations and Signal PathwaysHatice Kubra Basoglu1, Servet Celik2, Kubilay Dogan Kilic3, Turker Cavusoglu3,4, Gurkan Yigitturk1, Okan Bilge2, Yigit Uyanikgil3,4 and Mehmet Turgut5*
- *Corresponding Author:
- Mehmet Turgut
M.D., Ph.D., Department of Neurosurgery
Adnan Menderes University School of Medicine
Cumhuriyet Mahallesi, Adnan Menderes Bulvarı, Haltur
Apartmanı No: 6/7, 09020 Aydın, Turkey
Tel: +90 256 2134874
Fax: +90 256 2120146
E-mail: [email protected]
Received date: January 02, 2017; Accepted date: January 19, 2017; Published date: January 21, 2017
Citation: Basoglu HK, Celik S, Kilic KD, Cavusoglu T, Yigitturk G, et al. (2017) Spina Bifida: Morphological Features, Molecular Regulations and Signal Pathways. J Spine 6:352. doi: 10.4172/2165-7939.1000352
Copyright: © 2017 Basoglu HK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The main aim of this article is to review the knowledge about the closure defect of the vertebral column calls spina bifida. The anatomic, embryologic and molecular biologic knowledge about this condition is reevaluated with checking the contentful dry bone collection. Determined spina bifida samples, types in any part of vertebral column reviewed under the light of increasing recent literature. The review also gives attention to the cervical, thoracic regional, anterior and partial closure defect possibilities and clinical conditions, which are not emphasized adequately and are thought as a separate case status but are severe or mild types of spina bifida. Most common sites, especially sacral region of spina bifida and present incidence in different nations assessed and compared with our dry bone series. Regional incidence, types and clinical conditions of spina bifida reviewed under the light of the recent embryologic and molecular biologic studies. This review will give tidy think and aspect of morphology and clinics of spina bifida throughout of the vertebral column.