Spindle Cell Carcinoma of the Lung: Benefits of Immunohistochemical Studies
Received Date: Feb 22, 2018 / Accepted Date: Mar 15, 2018 / Published Date: Mar 19, 2018
Sarcomatoid carcinoma is a rare histologic type of non-small cell lung cancers (NSCLC) which represents only 0.3 to 3% of primitive lung cancers.
In 2004, the World Health Organization (WHO) defined in its classification a new entity, sarcomatoid carcinoma, as “any proliferation that can offer permanently epithelial-mesenchymal morphological transition.”
The term sarcomatoid carcinoma is generic; it includes various entities such as spindle cell carcinomas which are without well-known clinical and immunohistochemical features.
We report the case of a 53-year-old smoker patient, with a history of bullous emphysema discovered 8 years ago and who was hospitalized for exploration of a large pleuro parenchymal mass. The functional signs were dyspnea and alteration of the condition. Percutaneous Computed Tomography (CT) guided biopsy of the mass concluded to a pulmonary spindle cell carcinoma. Staging revealed adrenal nodule with mesenteric and peritoneal invasions. The patient died two months after diagnosis despite an attempt of chemotherapy based on carboplatin/docetaxel.
Keywords: Lung cancer; Sarcomatoid carcinoma; Spindle cell; Immunohistochemistry
Citation: Feki W, Ketata W, Charfi S, Bahloul N, Yangui I, et al. (2018) Spindle Cell Carcinoma of the Lung: Benefits of Immunohistochemical Studies. J Pulm Respir Med 8: 449. Doi: 10.4172/2161-105X.1000449
Copyright: © 2018 Feki W, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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