alexa Spontaneous Chondrocyte Maturation on 3D-Chitosan Scaff
ISSN: 2157-7552

Journal of Tissue Science & Engineering
Open Access

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Research Article

Spontaneous Chondrocyte Maturation on 3D-Chitosan Scaffolds

Serafim M Oliveira1,2,3, Gloria Turner1, Simone P Rodrigues2,3, Mário A Barbosa3, Mani Alikhani1,4 and Cristina C Teixeira1,4,5*

1Consortium for Translational Orthodontic Research, New York University College of Dentistry, New York, USA

2Department of Mechanical Engineering, ESTV-Escola Superior de Tecnologia de Viseu, Viseu, Portugal

3INEB-Instituto de Engenharia Biomédica, Porto, Portugal

4Department of Orthodontics, New York University, College of Dentistry, New York, NY, USA

5Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, USA

Corresponding Author:
Cristina C Teixeira, DMD, MS, PhD
Department of Basic Science and Craniofacial Biology
New York University College of Dentistry
345 East 24th Street
New York, NY 10010, USA
Tel: +(212) 998- 9958
E-mail: [email protected]

Received date: January 03, 2013; Accepted date: February 12, 2013; Published date: February 15, 2013

Citation: Oliveira SM, Turner G, Rodrigues SP, Barbosa MA, Alikhani M, et al. (2013) Spontaneous Chondrocyte Maturation on 3D-Chitosan Scaffolds. J Tissue Sci Eng 4:124. doi:10.4172/2157-7552.1000124

Copyright: © 2013 Oliveira SM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



The endochondral ossification mechanism provides promising new insight into potential techniques for repairing bone defects. The methods for replicating endochondral ossification in culture, although diverse, have yet to identify a procedure that reflects natural conditions, while satisfying the practical, experimental needs for efficiency and maneuverability. In this study, we present a novel approach that addresses all of these concerns. Coordinated proliferation and differentiation of chondrocytes in a transient cartilage is required for endochondral bone growth, but the mechanisms and pathways that control these processes are not completely understood. For lack of alternative methods, chondrocyte cultures are commonly pushed to differentiation with growth factors and supplements, like retinoic acid. We have developed a tissue culture model, using a 3D-chitosan sponge, which supports the proliferation and differentiation of chondrocytes, without exposure to supplements, and which matures into a near replica of the growth plate.

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