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Spontaneous Fatal Tumor Lysis Syndrome in a Patient with T-Cell Lymphoblastic Lymphoma/Leukemia: Successful Treatment with Continuous Renal Replacement Therapy and Increasing-Dose Gradually Chemotherapy | Abstract
ISSN: 2165-7920

Journal of Clinical Case Reports
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Case Report

Spontaneous Fatal Tumor Lysis Syndrome in a Patient with T-Cell Lymphoblastic Lymphoma/Leukemia: Successful Treatment with Continuous Renal Replacement Therapy and Increasing-Dose Gradually Chemotherapy

Jing-Hua Liu, Fan Zhou*, Xiao-Lin Zhang, Yan-Qin Liu, Ji-Gang Wang and Ying Bai
Department of Hematology, General Hospital of Shenyang Command, PLA, Shenyang Liaoning 110016, China
Corresponding Author : Fan Zhou
Department of Hematology, General Hospital of Shenyang Command
PLA, Shenyang Liaoning, China, 110016
Tel: 86-24-28851223
Fax: 86-24-28856233
E-mail: [email protected]
Received February 16, 2014; Accepted March 22, 2014; Published March 24, 2014
Citation: Liu JH, Zhou F, Zhang XL, Liu YQ, Wang JG, et al. (2014) Spontaneous Fatal Tumor Lysis Syndrome in a Patient with T-Cell Lymphoblastic Lymphoma/Leukemia: Successful Treatment with Continuous Renal Replacement Therapy and Increasing-Dose Gradually Chemotherapy. J Clin Case Rep 4:361. doi:10.4172/2165-7920.1000361
Copyright: © 2014 Liu JH, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Tumor Lysis Syndrome (TLS) results from massive necrosis orapoptosis of large proliferating tumors and is characterized by marked hyper uricemia, hyperkalemia, and hyper phosphatemia secondaryto cell lysis and the metabolism of excessive nucleic acids. Clinically significant TLS, with end-organ compromise, occurs in approximately5% of all patients with hematologic malignancies and in up to 25% of highrisk patients, including those with T-cell acute lymphoblasticleukemia and Burkitt’s lymphoma. TLS is a phenomena frequently occurs after the initiation of therapy, while spontaneous TLS occurringin the absence of chemotherapy, is rare but might portend a worse prognosis. We present a case of spontaneous TLS treated successfullywith continuous renal replacement therapy and increasing-dosegradually chemotherapy in a boy with T-cell lymphoblastic lymphoma/leukemia.

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