alexa Spontaneous Intestinal Perforation is not Associated with the Recent Administration of Antenatal Betamethasone
ISSN: 2167-0897

Journal of Neonatal Biology
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Research Article

Spontaneous Intestinal Perforation is not Associated with the Recent Administration of Antenatal Betamethasone

Brian J Rau1, Marc G Weiss1, Jonathan K Muraskas1* and Carolyn Jones2
1Division of Neonatal-Perinatal Medicine, Maywood, Illinois, USA
2Division of Genetics, Department of Pediatrics Loyola University Medical Center, Maywood, Illinois, USA
Corresponding Author : Jonathan K Muraskas, MD
Division of Neonatal-Perinatal Medicine
Loyola University Medical Center
2160 S. 1st Avenue, 107-5810
Maywood, IL 60153, USA
Tel: (708) 216-1067
Fax: (708) 216-5602
E-mail: [email protected]
Received June 14, 2012; Accepted November 23, 2012; Published November 26, 2012
Citation: Rau BJ, Weiss MG, Muraskas JK, Jones C (2013) Spontaneous Intestinal Perforation is not Associated with the Recent Administration of Antenatal Betamethasone. J Neonatal Biol 2:112. doi:10.4172/2167-0897.1000112
Copyright: © 2013 Rau BJ, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Intestinal disease in premature infants, especially spontaneous intestinal perforation and necrotizing enterocolitis, contributes significant morbidity and mortality in very low birth weight infants and has a large impact in neonatal care and patient quality of life. In very low birth weight infants, factors influencing a systemic inflammatory response and/ or submucosal thinning, including postnatal glucocorticoids and exposure to indomethacin or ibuprofen, exacerbate the development of intestinal perforation in an already at risk population. In this retrospective analysis we evaluated whether antenatal steroids, a glucocorticoid for fetal lung maturity often given to mothers in close proximity to delivery, may be related to the development of perforation when given close to delivery and without adequate time for recovery of the intestinal mucosa. In our data set, it did not appear to be significantly related. Our results also did not show a categorical association between antenatal steroids and spontaneous intestinal perforation. We did however show a significant relationship between smaller, more depressed infants developing spontaneous intestinal perforation, as well as an association with concomitant sepsis

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