alexa Spontaneous One-Lung Ventilation Increases the Lung Inflammatory Response: An Experimental Pilot Study | OMICS International | Abstract
ISSN: 2155-6148

Journal of Anesthesia & Clinical Research
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Spontaneous One-Lung Ventilation Increases the Lung Inflammatory Response: An Experimental Pilot Study

Humberto S Machado1*, Paula Sá1, Catarina S Nunes2, António Couceiro3, Álvaro Moreira da Silva4 and Artur Águas5

1Anesthesiology Department, Centro Hospitalar do Porto, Largo Abel Salazar, 4099-001 Porto, Portugal

2Open University, Department of Science and Technology and Anesthesiology Department, Centro Hospitalar do Porto, Largo Abel Salazar, 4099-001 Porto, Portugal

3Pathological Anatomy service, Gaia/Espinho Hospital Centre, Rua Conceição Fernandes, 4430 Vila Nova de Gaia, Portugal

4Intensive care Service, Port Hospital Center, Largo Abel Salazar, 4099-001 Porto, Portugal

5Department of Normal Anatomy, Abel Salazar Biomedical Sciences Institute-University of Porto and Multidisciplinary Biomedical Research Unit, St. Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal

*Corresponding Author:
Humberto S Machado
Department, Centro Hospitalar do Porto
Largo Abel Salazar, 4099-001 Porto, Portugal
Tel: 351 935848475
Fax: 351 220900644
E-mail: [email protected]

Received date: May 28, 2014; Accepted date: August 01, 2014; Published date: August 11, 2014

Citation: Machado HS, Sá P, Nunes CS, Couceiro A, da Silva ÁM, et al. (2014) Spontaneous One-Lung Ventilation Increases the Lung Inflammatory Response: An Experimental Pilot Study. J Anesth Clin Res 5:428. doi: 10.4172/2155-6148.1000428

Copyright: © 2014 Machado HS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Study objective: The purpose of this study was to investigate if spontaneous one-lung ventilation would induce any type of inflammatory lung response when compared to spontaneous two-lung ventilation and its intensity, by quantification of inflammatory cells in lung histology at the end of the procedure.

Design: In vivo prospective randomised animal study

Setting: University research laboratory

Subjects: New Zealand rabbits Interventions: Rabbits (n=20) were randomly assigned to 4 groups (n=5 each group). Groups 1 and 2 were submitted to one-lung ventilation, during 20 and 75 minutes respectively; groups 3 and 4 were submitted to two-lung ventilation during 20 and 75 minutes and considered controls. Ketamine/xylazine was administered for induction and maintenance of anesthesia. One-lung ventilation was achieved by administration of air into the interpleural space, and left lung collapse was visually confirmed through the centre of the diaphragm.

Measurements: Lung histology preparations were observed under light microscopy for quantification of the inflammatory response (light, moderate and severe).

Main results: All subjects had at least light inflammatory response. However, rabbits submitted to one-lung ventilation had a statistically significant value for the occurrence of moderate inflammation (p<0.05). The inflammatory response found included mainly eosinophils, with an average proportion of 75/25 to other polymorphonuclear cells. No differences between groups were found regarding gas exchange, heart rate and respiratory rate.

Conclusions: In this spontaneous one-lung ventilation model, lung collapse was positively associated with a greater inflammatory response when compared to normal two-lung ventilation.


Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version