alexa Spontaneous Remission of Primary Hyperparathyroidism in
ISSN: 2165-7920

Journal of Clinical Case Reports
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Case Report

Spontaneous Remission of Primary Hyperparathyroidism in a Patient with Neurofibromatosis Type 1: Case Report

França MM1, Santos AB1, Hirosawa RM1, Souza GL1, Tagliarini JV2, Mazeto GMFS1 and Nunes VS1*
1Department of Internal Medicine, Botucatu Medical School, Sao Paulo, State University/Unesp, Sao Paulo, Brazil
2Department of Ophthalmology and Otolaryngology, Botucatu Medical School, Sao Paulo, State University/Unesp, Sao Paulo, Brazil
Corresponding Author : Vania dos Santos Nunes
Department of Internal Medicine
Botucatu Medical School, Sao Paulo
State University/Unesp, Sao Paulo, Brazil
Tel: 55 14 3811 62 13
Fax: 55 14 3882 22 38
E-mail: [email protected]
Received May 02, 2012; Accepted June 15, 2012; Published June 25, 2012
Citation: França MM, Santos AB, Hirosawa RM, Souza GL, Tagliarini JV, et al. (2012) Spontaneous Remission of Primary Hyperparathyroidism in a Patient with Neurofibromatosis Type 1: Case Report. J Clin Case Rep 2:156. doi:10.4172/2165-7920.1000156
Copyright: © 2012 França MM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Neurofibromatosis type 1 (NF1) is an autosomal dominant multisystem disorder affecting approximately 1 in 3500 individuals. Patients with the disorder can develop carcinoid tumors, medullary thyroid carcinoma, pheochromocytoma and tumor of the hypothalamus. The association of NF1 with Primary Hyperparathyroidism (HPP) is very rare. We report a 56-year-old woman with NF1 who was referred to our service because of nephrolithiasis. Physical examination revealed the characteristic signs of NF1, and her laboratory calcium profile was compatible with HPP. The patient was referred for parathyroidectomy, but during the surgical work-up she underwent spontaneous remission of her HPP. This case is significant not only for the rarity of this presentation in NF1 patients, but also because of the spontaneous remission of HPP.

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