Case Report
Spread through Air Spaces Detected in Frozen Sections of Lung Adenocarcinoma is a Sign of Air Space Invasion: A Case Report
Noriah Binti Othman1,2, Yuko Akazawa1,3, Yuka Kitamura1,4, Mikiko Hashisako1, Tomoshi Tsuchiya3, Naoya Yamazaki3, Takeshi Nagayasu3 and Junya Fukuoka1*1Department of Pathology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
2Department of Pathology, Serdang Hospital, Selangor, Malaysia
3Department of Gastroenterology and Hepatology, Nagasaki University, Japan
4Department of Surgical Oncology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
- *Corresponding Author:
- Junya Fukuoka
Department of Pathology, Graduate School of Biomedical Sciences
Nagasaki University, 1-7-1, Sakamoto, Nagasaki-852-8523, Japan
Tel: +81-95-819-7055
Fax: +81-95-819-7056
E-mail: [email protected]
Received date: October 29, 2016; Accepted date: December 30, 2016; Published date: December 31, 2016
Citation: Othman NB, Akazawa Y, Kitamura Y, Hashisako M, Tsuchiya T, et al. (2016) Spread through Air Spaces Detected in Frozen Sections of Lung Adenocarcinoma is a Sign of Air Space Invasion: A Case Report. J Pulm Respir Med 6:384. doi: 10.4172/2161-105X.1000384
Copyright: © 2016 Othman NB, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
| Peer-reviewed Full Article 
Abstract
A 70-year-old non-smoking woman was found to have 23 mm sized lung adenocarcinoma. Intraoperative frozen sections were performed which confirmed the diagnosis of adenocarcinoma. Surgical material revealed presence of tumor nests spreading through airspaces (STAS) as far as 9 mm from the edge of the main tumor. Based on the presence of STAS, resection of the remaining left upper lobe was performed after the first operation, and no residual tumor or STAS was detected. A retrospective review of the frozen sections showed the presence of STAS. This report indicates that evaluation of STAS at the time of surgery may help improve the clinical course of a patient undergoing limited resection.
